Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease

被引：89

作者：

De Cruz, Peter ^{[1
,2
]}

Prideaux, Lani ^{[1
,2
]}

Wagner, Josef

Ng, Siew C. ^{[3
,4
]}

McSweeney, Chris

Kirkwood, Carl

Morrison, Mark

Kamm, Michael A. ^{[1
,2
]}

机构：

[1] St Vincents Hosp, Melbourne, Vic 3065, Australia

[2] Univ Melbourne, Melbourne, Vic 3010, Australia

[3] Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[4] Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

来源：

INFLAMMATORY BOWEL DISEASES | 2012年 / 18卷 / 02期

关键词：

enteric bacterial flora; inflammatory bowel disease; metagenomic; microbiota; 16S RIBOSOMAL-RNA; INVASIVE ESCHERICHIA-COLI; AVIUM SUBSPECIES PARATUBERCULOSIS; GRADIENT GEL-ELECTROPHORESIS; IN-SITU HYBRIDIZATION; MUCOSA-ASSOCIATED BACTERIA; FORMULA-FED INFANTS; MAGNETIC-RESONANCE-SPECTROSCOPY; ANTIBIOTIC COMBINATION THERAPY; BUTYRATE-PRODUCING BACTERIA;

D O I：

10.1002/ibd.21751

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated. (Inflamm Bowel Dis 2011;)

引用

页码：372 / 390

页数：19

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