Substituted pyrazolo[3,4-d]pyrimidines:: Microwave-assisted, solvent-free synthesis and biological evaluation

被引：22

作者：

Oliveira-Campos, Ana M. F. ^{[1
]}

Sivasubramanian, Aravind ^{[1
]}

Rodrigues, Ligia M. ^{[1
]}

Seijas, Julio A. ^{[2
]}

Pilar Vazquez-Tato, M. ^{[2
]}

Peixoto, Francisco ^{[3
]}

Abreu, Carlos G. ^{[4
]}

Cidade, Honorina ^{[5
]}

Oliveira, Ana Elizabete ^{[5
]}

Pinto, Madalena ^{[5
]}

机构：

[1] Univ Minho, Ctr Quim, PT-4710057 Braga, Portugal

[2] Univ Santiago de Compostela, Fac Ciencias, Dept Quim Organ, ES-27080 Lugo, Spain

[3] UTAD, CECAV, PT-5001801 Vila Real, Portugal

[4] UTAD, Dept Plant Protect, PT-5001801 Vila Real, Portugal

[5] Univ Porto, Fac Farm, Lab Quim Organ, CEQOFFUP, PT-4050047 Oporto, Portugal

来源：

HELVETICA CHIMICA ACTA | 2008年 / 91卷 / 07期

关键词：

D O I：

10.1002/hlca.200890145

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines by using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.

引用

页码：1336 / 1345

页数：10

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