The impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma: an intent-to-transplant analysis

被引：8

作者：

Selberg, Lorenz ^{[1
]}

Stadtherr, Peter ^{[1
]}

Dietrich, Sascha ^{[1
]}

Tran, T. Hien ^{[2
]}

Luft, Thomas ^{[1
]}

Hegenbart, Ute ^{[1
]}

Bondong, Andrea ^{[1
]}

Meissner, Julia ^{[1
]}

Liebers, Nora ^{[1
]}

Schmitt, Michael ^{[1
]}

Ho, Anthony Dick ^{[1
]}

Mueller-Tidow, Carsten ^{[1
]}

Dreger, Peter ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Med 5, Heidelberg, Germany

[2] Heidelberg Univ, Inst Immunol, Heidelberg, Germany

来源：

BONE MARROW TRANSPLANTATION | 2021年 / 56卷 / 01期

关键词：

CLINICAL-PRACTICE GUIDELINES; FOLLICULAR LYMPHOMA; BRENTUXIMAB VEDOTIN; CONSENSUS PROJECT; MYELOID-LEUKEMIA; UNRELATED DONOR; EUROPEAN-GROUP; BLOOD; MULTICENTER; RITUXIMAB;

D O I：

10.1038/s41409-020-0976-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Purpose of this single-centre retrospective study was to assess the outcome of allogeneic hematopoietic cell transplantation (alloHCT) for relapsed/refractory (r/r) non-Hodgkin lymphoma (NHL) by intent-to-transplant (ITT). Included were all consecutive patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and peripheral T-cell lymphoma (PTCL) for whom a donor search was performed between 2004 and 2018. Primary endpoint was overall survival (OS) measured from search initiation. A donor search was initiated for 189 patients (DLBCL 61, FL 32, MCL 43, and PTCL 53), with 76% of the patients having active disease. OS at 5 years after search initiation for DLBCL, FL, MCL, and PTCL was 26%, 44%, 52%, and 50%, respectively. AlloHCT was performed in 137 patients (72%; DLBCL 64%). Main reason for not undergoing alloHCT was disease progression, whereas donor unavailability accounted for only 4% of pretransplantation failures. These results suggest that survival of patients with r/r NHL entering the alloHCT route may be overestimated by a factor of 1.2-1.4 if based on actually transplanted patients only. This effect should be taken into account when using alloHCT as benchmark for new therapeutic approaches for the treatment of poor-risk NHL.

引用

页码：30 / 37

页数：8

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