Current concepts:: Hepatopulmonary syndrome -: A liver-induced lung vascular disorder

被引:414
作者
Rodriguez-Roisin, Roberto [1 ]
Krowka, Michael J.
机构
[1] IDIBAPS, Hosp Clin, Serv Pneumol, Inst Torax, E-08036 Barcelona, Spain
[2] Univ Barcelona, Barcelona, Spain
[3] Mayo Clin, Div Pulm & Crit Care, Rochester, MN USA
关键词
D O I
10.1056/NEJMra0707185
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The hepatopulmonary syndrome is characterized by defects in oxygenation due to pulmonary abnormalities associated with chronic liver disease. Dyspnea and hypoxemia can be severe and often worsen in the upright position. Gross dilatation of the precapillary and capillary vessels occurs with ventilation-perfusion mismatch. The syndrome usually improves after liver transplantation. Copyright © 2008 Massachusetts Medical Society. All rights reserved.
引用
收藏
页码:2378 / 2387
页数:10
相关论文
共 50 条
  • [1] DIAGNOSTIC UTILITY OF CONTRAST ECHOCARDIOGRAPHY AND LUNG PERFUSION SCAN IN PATIENTS WITH HEPATOPULMONARY SYNDROME
    ABRAMS, GA
    JAFFE, CC
    HOFFER, PB
    BINDER, HJ
    FALLON, MB
    [J]. GASTROENTEROLOGY, 1995, 109 (04) : 1283 - 1288
  • [2] Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: A new approach
    Abrams, GA
    Nanda, NC
    Dubovsky, EV
    Krowka, MJ
    Fallon, MB
    [J]. GASTROENTEROLOGY, 1998, 114 (02) : 305 - 310
  • [3] Implications of estradiol and progesterone in pulmonary vasodilatation in cirrhotic patients
    Aller, R
    Moya, JL
    Avila, S
    Villa, J
    Moreira, V
    Bárcena, R
    Boxeida, D
    de Luis, DA
    [J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2002, 25 (01) : 4 - 10
  • [4] Carboxyhemoglobin levels in cirrhotic patients with and without hepatopulmonary syndrome
    Arguedas, MR
    Drake, BB
    Kapoor, A
    Fallon, MB
    [J]. GASTROENTEROLOGY, 2005, 128 (02) : 328 - 333
  • [5] Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation
    Arguedas, MR
    Abrams, GA
    Krowka, MJ
    Fallon, MB
    [J]. HEPATOLOGY, 2003, 37 (01) : 192 - 197
  • [6] Resolution of gas exchange abnormalities and intrapulmonary shunting following liver transplantation
    Battaglia, SE
    Pretto, JJ
    Irving, LB
    Jones, RM
    Angus, PW
    [J]. HEPATOLOGY, 1997, 25 (05) : 1228 - 1232
  • [7] ARTERIAL CHANGES IN LUNGS IN CIRRHOSIS OF LIVER - LUNG SPIDER NEVI
    BERTHELO.P
    WALKER, JG
    SHERLOCK, S
    REID, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1966, 274 (06) : 291 - &
  • [8] Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome
    Carter, EP
    Hartsfield, CL
    Miyazono, M
    Jakkula, M
    Morris, KG
    McMurtry, IF
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 283 (02) : L346 - L353
  • [9] Inhibition of KCa channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis
    Carter, EP
    Sato, K
    Morio, Y
    McMurtry, IF
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 279 (05) : L903 - L910
  • [10] ELEVATED EXHALED NITRIC-OXIDE IN PATIENTS WITH HEPATOPULMONARY SYNDROME
    CREMONA, G
    HIGENBOTTAM, TW
    MAYORAL, V
    ALEXANDER, G
    DEMONCHEAUX, E
    BORLAND, C
    ROE, P
    JONES, GJ
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (11) : 1883 - 1885