Current concepts:: Hepatopulmonary syndrome -: A liver-induced lung vascular disorder

被引:422
作者
Rodriguez-Roisin, Roberto [1 ]
Krowka, Michael J.
机构
[1] IDIBAPS, Hosp Clin, Serv Pneumol, Inst Torax, E-08036 Barcelona, Spain
[2] Univ Barcelona, Barcelona, Spain
[3] Mayo Clin, Div Pulm & Crit Care, Rochester, MN USA
关键词
D O I
10.1056/NEJMra0707185
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The hepatopulmonary syndrome is characterized by defects in oxygenation due to pulmonary abnormalities associated with chronic liver disease. Dyspnea and hypoxemia can be severe and often worsen in the upright position. Gross dilatation of the precapillary and capillary vessels occurs with ventilation-perfusion mismatch. The syndrome usually improves after liver transplantation. Copyright © 2008 Massachusetts Medical Society. All rights reserved.
引用
收藏
页码:2378 / 2387
页数:10
相关论文
共 50 条
[1]   DIAGNOSTIC UTILITY OF CONTRAST ECHOCARDIOGRAPHY AND LUNG PERFUSION SCAN IN PATIENTS WITH HEPATOPULMONARY SYNDROME [J].
ABRAMS, GA ;
JAFFE, CC ;
HOFFER, PB ;
BINDER, HJ ;
FALLON, MB .
GASTROENTEROLOGY, 1995, 109 (04) :1283-1288
[2]   Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: A new approach [J].
Abrams, GA ;
Nanda, NC ;
Dubovsky, EV ;
Krowka, MJ ;
Fallon, MB .
GASTROENTEROLOGY, 1998, 114 (02) :305-310
[3]   Implications of estradiol and progesterone in pulmonary vasodilatation in cirrhotic patients [J].
Aller, R ;
Moya, JL ;
Avila, S ;
Villa, J ;
Moreira, V ;
Bárcena, R ;
Boxeida, D ;
de Luis, DA .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2002, 25 (01) :4-10
[4]   Carboxyhemoglobin levels in cirrhotic patients with and without hepatopulmonary syndrome [J].
Arguedas, MR ;
Drake, BB ;
Kapoor, A ;
Fallon, MB .
GASTROENTEROLOGY, 2005, 128 (02) :328-333
[5]   Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation [J].
Arguedas, MR ;
Abrams, GA ;
Krowka, MJ ;
Fallon, MB .
HEPATOLOGY, 2003, 37 (01) :192-197
[6]   Resolution of gas exchange abnormalities and intrapulmonary shunting following liver transplantation [J].
Battaglia, SE ;
Pretto, JJ ;
Irving, LB ;
Jones, RM ;
Angus, PW .
HEPATOLOGY, 1997, 25 (05) :1228-1232
[7]   ARTERIAL CHANGES IN LUNGS IN CIRRHOSIS OF LIVER - LUNG SPIDER NEVI [J].
BERTHELO.P ;
WALKER, JG ;
SHERLOCK, S ;
REID, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1966, 274 (06) :291-&
[8]   Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome [J].
Carter, EP ;
Hartsfield, CL ;
Miyazono, M ;
Jakkula, M ;
Morris, KG ;
McMurtry, IF .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 283 (02) :L346-L353
[9]   Inhibition of KCa channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis [J].
Carter, EP ;
Sato, K ;
Morio, Y ;
McMurtry, IF .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 279 (05) :L903-L910
[10]   ELEVATED EXHALED NITRIC-OXIDE IN PATIENTS WITH HEPATOPULMONARY SYNDROME [J].
CREMONA, G ;
HIGENBOTTAM, TW ;
MAYORAL, V ;
ALEXANDER, G ;
DEMONCHEAUX, E ;
BORLAND, C ;
ROE, P ;
JONES, GJ .
EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (11) :1883-1885