The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares

被引:7
作者
Cuervo-Arango, J. [1 ]
机构
[1] Univ CEU Cardenal Herrera, Fac Vet, Dept Med & Cirugia Anim, Valencia 46113, Spain
关键词
Flunixin meglumine; Prostaglandin inhibition; Ovulation failure; Luteal function; Mare; INDUCTION; FOLLICLES; PROSTAGLANDINS;
D O I
10.1016/j.anireprosci.2011.07.008
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Flunixin meglumine (FM), a prostaglandin synthetase inhibitor, causes ovulatory failure in the mare. However, the effect of the FM treatment relative to the time of hCG administration on the ovulation failure has not been determined nor has its effect on the luteal function of treated mares. Estrous mares with a follicle >= 32 mm (range of 32-38 mm) were treated with 1.7 mg/kg b.w. of FM iv at zero, 12,24 and 36 h (n = 6), at 24 and 36 h (n = 6), at 28 and 36 h (n = 6), at 24 h (n = 6) or at 30 h (n = 6) after treatment with 1500 Ill hCG. One group received no FM (control, n = 6). Progesterone concentrations were determined using RIA. Mares treated with FM 0-36 h and 24-36 h had higher (P < 0.05) incidence of ovulatory failure (83 and 80%, respectively) than mares treated twice at 28 and 36 h, or once at 24 or at 30 h after hCG (16.7, 0 and 0%, respectively). The anovulatory follicles of FM treated mares luteinized and produced progesterone (>2 ng/ml). The progesterone concentration was lower in mares treated with FM at zero to 36 h and at 24-36 h after hCG than in the other groups. In conclusion, the FM administration was effective in blocking ovulation only when the treatment began <= 24 h after hCG and was continued every 12 h until >= 36 h. In addition, the FM-induced anovulatory follicles underwent luteinization of follicular cells with active production of progesterone. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:84 / 90
页数:7
相关论文
共 18 条
[1]  
ARMSTRONG DT, 1981, J REPROD FERTIL, V62, P283
[2]  
CHAY S, 1982, Equine Practice, V4, P16
[3]   Systemic treatment with high dose of flunixin-meglumine is able to block ovulation in mares by inducing hemorrhage and luteinisation of follicles [J].
Cuervo-Arango, J. ;
Domingo-Ortiz, R. .
THERIOGENOLOGY, 2011, 75 (04) :707-714
[4]   Plasma LH concentrations after administration of human chorionic gonadotropin to estrous mares [J].
Evans, M. J. ;
Gastal, E. L. ;
Silva, L. A. ;
Gastal, M. O. ;
Kitson, N. E. ;
Alexander, S. L. ;
Irvine, C. H. G. .
ANIMAL REPRODUCTION SCIENCE, 2006, 94 (1-4) :191-194
[5]   Treatment with human chorionic gonadotropin (hCG) for ovulation induction is associated with an immediate 17β-estradiol decrease and a more rapid LH increase in mares [J].
Ginther, O. J. ;
Beg, M. A. ;
Gastal, E. L. ;
Gastal, M. O. ;
Cooper, D. A. .
ANIMAL REPRODUCTION SCIENCE, 2009, 114 (1-3) :311-317
[6]   Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study [J].
Ginther, OJ ;
Beg, MA ;
Gastal, EL ;
Gastal, MO ;
Baerwald, AR ;
Pierson, RA .
REPRODUCTION, 2005, 130 (03) :379-388
[7]  
Ginther OJ, 1995, ULTRASONIC IMAGING A, V2
[8]   COMPARISON OF HCG, BUSERELIN AND LUPROSTIOL FOR INDUCTION OF OVULATION IN CYCLING MARES [J].
HARRISON, LA ;
SQUIRES, EL ;
MCKINNON, AO .
JOURNAL OF EQUINE VETERINARY SCIENCE, 1991, 11 (03) :163-166
[9]   PROSTAGLANDIN ENDOPEROXIDE SYNTHASE IN RAT OVARIAN FOLLICLES - CONTENT, CELLULAR-DISTRIBUTION, AND EVIDENCE FOR HORMONAL INDUCTION PRECEDING OVULATION [J].
HEDIN, L ;
GADDYKURTEN, D ;
KURTEN, R ;
DEWITT, DL ;
SMITH, WL ;
RICHARDS, JS .
ENDOCRINOLOGY, 1987, 121 (02) :722-731
[10]  
HIGGINS AJ, 1986, BRIT VET J, V142, P163, DOI 10.1016/0007-1935(86)90093-X