Study on the synthesis, characterization, crystal structure and anticancer acitivity of a bridging ligand complex of Cu(II) with 2,2′-bipyridine and demethylcantharate

A bridging ligand compound [(bipy)(DCA)Cu-(DCA)-Cu(bipy))H2O)].3H(2)O (bipy=2,2'-bipyridine, DCA= demethylcantharate) has been synthesized by copper chloride dihydrate, 2,2'-bipyridine and disodium demethylcantharate. The structure was characterized by elemental analysis, IR, UV spectra and conductance. The crystal structure was determined by X-ray single crystal diffraction. The crystal having empirical formula Cu2CH40N4O14 belongs to triclinic with space group P (1) over bar, alpha =1.1251 (2) nm, b = 1. 2707 (3) nm, c = 1.7345 (4) nm, alpha = 94.86(3)degrees, beta=107.61(3)degrees, gamma = 112.50(3)degrees, V = 2.1264(7) nm(3), mu = 1.066 mm(-1), Z = 2, D-c = 1.374 g/ cm(3), F (000) 908, R = 0. 0547, wR(2) = 0.1355, GOF = 0.815, in which the copper atoms are six-coordinated in a stretched aberration octahedral geometry. The compound was tested in vitro against human tumor cell lines, HL-60, BGC-823, Bel-7402 and Hela, and displayed high activity.