Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling

被引：9
作者：
Gomes, Marta T. [1 ]
Bai, Yang [1 ,2 ]
Potje, Simone R. [1 ,3 ]
Zhang, Lu [4 ]
Lockett, Angelia D. [1 ]
Machado, Roberto F. [1 ]
机构：
[1] Indiana Univ Sch Med, Div Pulm Crit Care Sleep & Occupat Med, Indianapolis, IN 46202 USA
[2] China Med Univ, Sch Pharm, Dept Clin Pharmacol, Shenyang 110122, Peoples R China
[3] Minas Gerais State Univ UEMG, Dept Biol Sci, BR-37900106 Passos, Brazil
[4] China Med Univ, Sch Pharm, Dept Ion Channel Pharmacol, Shenyang 110122, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 05期
关键词：
pulmonary arterial hypertension; vascular remodeling; signaling pathways; metabolism; inflammation; PYRUVATE-KINASE M2; SMOOTH-MUSCLE-CELLS; POSITRON-EMISSION-TOMOGRAPHY; ARTERIAL-HYPERTENSION; ENDOTHELIAL DYSFUNCTION; MITOCHONDRIAL DYSFUNCTION; RIGHT VENTRICLE; DIFFERENTIAL REGULATION; OXIDATIVE STRESS; CA2+ SIGNALS;
D O I：
10.3390/ijms23052410
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by (mal)adaptive remodeling of the pulmonary vasculature, which is associated with inflammation, fibrosis, thrombosis, and neovascularization. Vascular remodeling in PAH is associated with cellular metabolic and inflammatory reprogramming that induce profound endothelial and smooth muscle cell phenotypic changes. Multiple signaling pathways and regulatory loops act on metabolic and inflammatory mediators which influence cellular behavior and trigger pulmonary vascular remodeling in vivo. This review discusses the role of bioenergetic and inflammatory impairments in PAH development.
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页数：24
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  • [1] WWOX somatic ablation in skeletal muscles alters glucose metabolism
    Abu-Remaileh, Muhannad
    Abu-Remaileh, Monther
    Akkawi, Rania
    Knani, Ibrahim
    Udi, Shiran
    Pacold, Micheal E.
    Tam, Joseph
    Aqeilan, Rami, I
    [J]. MOLECULAR METABOLISM, 2019, 22 : 132 - 140
  • [2] Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension
    Afolayan, Adeleye J.
    Eis, Annie
    Alexander, Maxwell
    Michalkiewicz, Teresa
    Teng, Ru-Jeng
    Lakshminrusimha, Satyan
    Konduri, Girija G.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 310 (01) : L40 - L49
  • [3] Differential regulation of autophagy and mitophagy in pulmonary diseases
    Aggarwal, Saurabh
    Mannam, Praveen
    Zhang, Jianhua
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 311 (02) : L433 - L452
  • [4] Differential Regulation of Pulmonary Vascular Cell Growth by Hypoxia-Inducible Transcription Factor-1α and Hypoxia-Inducible Transcription Factor-2α
    Ahmad, Aftab
    Ahmad, Shama
    Malcolm, Kenneth C.
    Miller, Stacy M.
    Hendry-Hofer, Tara
    Schaack, Jerome B.
    White, Carl W.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013, 49 (01) : 78 - 85
  • [5] Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
    Akers, IA
    Parsons, M
    Hill, MR
    Hollenberg, MD
    Sanjar, S
    Laurent, GJ
    McAnulty, RJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 278 (01) : L193 - L201
  • [6] Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension
    Archer, Stephen L.
    [J]. CIRCULATION, 2017, 136 (25) : 2486 - 2490
  • [7] Mitochondrial Dynamics - Mitochondrial Fission and Fusion in Human Diseases
    Archer, Stephen L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (23) : 2236 - 2251
  • [8] Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension
    Archer, Stephen L.
    Fang, Yong-Hu
    Ryan, John J.
    Piao, Lin
    [J]. PULMONARY CIRCULATION, 2013, 3 (01) : 144 - 152
  • [9] Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension A Basis for Excessive Cell Proliferation and a New Therapeutic Target
    Archer, Stephen L.
    Marsboom, Glenn
    Kim, Gene H.
    Zhang, Hannah J.
    Toth, Peter T.
    Svensson, Eric C.
    Dyck, Jason R. B.
    Gomberg-Maitland, Mardi
    Thebaud, Bernard
    Husain, Aliya N.
    Cipriani, Nicole
    Rehman, Jalees
    [J]. CIRCULATION, 2010, 121 (24) : 2661 - U108
  • [10] The Genetics of Pulmonary Arterial Hypertension
    Austin, Eric D.
    Loyd, James E.
    [J]. CIRCULATION RESEARCH, 2014, 115 (01) : 189 - 202
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