Alginate inserts loaded with epidermal growth factor for the treatment of keratoconjunctivitis sicca

被引：1
作者：
Koelwel, Christoph [1 ]
Rothschenk, Stefan [1 ]
Fuchs-Koelwel, Barbara [2 ]
Gabler, Bernhard [2 ]
Lohmann, Chris [2 ]
Goepferich, Achim [1 ]
机构：
[1] Univ Regensburg, Lehrstuhl Pharmazeut Technol, D-93040 Regensburg, Germany
[2] Univ Regensburg, Univ Eye Clin, D-8400 Regensburg, Germany
来源：
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2008年 / 13卷 / 03期
关键词：
dry eye; ocular insert; alginates; EGF;
D O I：
10.1080/10837450801949566
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We developed and tested ocular inserts containing epidermal growth factor (EGF) for a causal treatment of keratoconjunctivitis sicca (KCS). The inserts, consisting of different alginates with hydroxyethylcellulose (HEC) as a lubricant and release modifier, released EGF over time periods ranging from a few hours up to several days. The stability of EGF was high, having a protein half-life of approximately 548 days. A clinical pilot study suggests an amelioration of both the main symptoms and the objective criteria: tear film break-up (BUT) time and lissamine green score. Our results show that EGF treatment of KCS is highly promising.
引用
收藏
页码：221 / 231
页数：11
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