Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

被引：74

作者：

Nakajima, Hideki ^{[1
]}

Nakajima, Kimiko ^{[1
]}

Tarutani, Masahito ^{[1
]}

Morishige, Ryuji ^{[2
]}

Sano, Shigetoshi ^{[1
]}

机构：

[1] Kochi Univ, Kochi Med Sch, Dept Dermatol, Nankoku, Kochi 7838505, Japan

[2] Janssen Pharmaceut KK, Sci Affairs, Chiyoda Ku, Tokyo 1010065, Japan

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2011年 / 303卷 / 06期

关键词：

IL-6; IL-21; IL-22; Resistin; Adiponectin; HMW-adiponectin; METABOLIC SYNDROME; INSULIN-RESISTANCE; ADIPONECTIN; PREVALENCE; EXPRESSION; OBESITY; DIFFERENTIATION; KERATINOCYTES; INFLAMMATION; VULGARIS;

D O I：

10.1007/s00403-011-1159-3

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-alpha, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high prevalence of the MS. In this study, we investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients. Our study identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients. Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index (PASI). In contrast, serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI.

引用

页码：451 / 455

页数：5

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