Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

被引：429

作者：

Greiner, D

Bonaldi, T

Eskeland, R

Roemer, E

Imhof, A

机构：

[1] Univ Munich, Histone Modificat Grp, Adolf Butenandt Inst, Dept Mol Biol, D-80336 Munich, Germany

[2] Leibniz Inst Nat Forsch & Infekt Biol, Hans Knoll Inst Nat Forsch, Abt Mol Nat Forsch, D-07745 Jena, Germany

来源：

NATURE CHEMICAL BIOLOGY | 2005年 / 1卷 / 03期

关键词：

D O I：

10.1038/nchembio721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone methylation plays a key role in establishing and maintaining stable gene expression patterns during cellular differentiation and embryonic development. Here, we report the characterization of the fungal metabolite chaetocin as the first inhibitor of a lysine-specific histone methyltransferase. Chaetocin is specific for the methyltransferase SU(VAR) 3-9 both in vitro and in vivo and may therefore be used to study heterochromatin-mediated gene repression.

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页码：143 / 145

页数：3

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