Horizontal Transmission of Clonal Cancer Cells Causes Leukemia in Soft-Shell Clams

被引：151

作者：

Metzger, Michael J. ^{[1
]}

Reinisch, Carol ^{[2
]}

Sherry, James ^{[2
]}

Goff, Stephen P. ^{[1
]}

机构：

[1] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[2] Environm Canada, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada

来源：

CELL | 2015年 / 161卷 / 02期

基金：

美国国家卫生研究院;

关键词：

FACIAL-TUMOR DISEASE; MOLLUSK MYA-ARENARIA; HEMIC NEOPLASIA; HEMATOPOIETIC NEOPLASIA; SOFTSHELL CLAMS; FLOW-CYTOMETRY; POPULATIONS; INDUCTION; PREVALENCE; ACTIVATION;

D O I：

10.1016/j.cell.2015.02.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Outbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to massive population loss. The cause of the disease is unknown. We recently identified a retrotransposon, Steamer, that is highly expressed and amplified to high copy number in neoplastic cells of soft-shell clams (Mya arenaria). Through analysis of Steamer integration sites, mitochondrial DNA single-nucleotide polymorphisms (SNPs), and polymorphic microsatellite alleles, we show that the genotypes of neoplastic cells do not match those of the host animal. Instead, neoplastic cells from dispersed locations in New York, Maine, and Prince Edward Island (PEI), Canada, all have nearly identical genotypes that differ from those of the host. These results indicate that the cancer is spreading between animals in the marine environment as a clonal transmissible cell derived from a single original clam. Our findings suggest that horizontal transmission of cancer cells is more widespread in nature than previously supposed.

引用

页码：255 / 263

页数：9

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