The role of 18F-FDG PET/CT imaging in Waldenstrom macroglobulinemia

被引:42
作者
Banwait, Ranjit [1 ]
O'Regan, Kevin [1 ]
Campigotto, Federico [1 ]
Harris, Brianna [1 ]
Yarar, Dilek [1 ]
Bagshaw, Meghan [1 ]
Leleu, Xavier [1 ,2 ]
Leduc, Renee [1 ]
Ramaiya, Nikhil [1 ]
Weller, Edie [1 ]
Ghobrial, Irene M. [1 ]
机构
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
[2] CHRU, Hop Huriez, Serv Malad Sang, Lille, France
关键词
POSITRON-EMISSION-TOMOGRAPHY; NON-HODGKINS-LYMPHOMA; CONSENSUS PANEL RECOMMENDATIONS; 2ND INTERNATIONAL WORKSHOP; THERAPEUTIC RESPONSE; FLUORODEOXYGLUCOSE; CHEMOTHERAPY; INDICATOR; CRITERIA; BONE;
D O I
10.1002/ajh.22044
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Disease assessment in WM is dependent on the quantification of the IgM monoclonal protein and percent involvement of the bone marrow. There is a need for imaging studies that objectively measure tumor load in these patients. In this study, we sought to examine the role of combined FDG-PET/CT imaging in the detection of tumor load and in the assessment of response to therapy. Thirty-five patients were enrolled on a prospective study using bortezomib and rituximab therapy and were included in this study because they completed a pre- and post-treatment FDG-PET/CT imaging at one facility (12 newly diagnosed and 23 relapsed/refractory). The use of combined FDG-PET/CT imaging showed positive findings in 83% of patients with WM, unlike prior studies using conventional imaging that indicate that only 20% of patients have lymphadenopathy or hepatosplenomegaly. Moreover, 43% of patients had abnormal bone marrow uptake on FDG-PET imaging that can potentially help in the assessment of their tumor load, especially with heterogenous sampling of the bone marrow. There was no statistical correlation between EORTC response criteria for FDG-PET/CT and response by monoclonal protein. This is the first study to examine the role of FDG-PET/CT imaging in WM. Future studies should examine the role of FDG-PET/CT in conjunction with monoclonal protein response in the assessment of progression-free survival in patients with WM. Am. J. Hematol. 86:567-572, 2011. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码:567 / 572
页数:6
相关论文
共 23 条
[1]   New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) [J].
Eisenhauer, E. A. ;
Therasse, P. ;
Bogaerts, J. ;
Schwartz, L. H. ;
Sargent, D. ;
Ford, R. ;
Dancey, J. ;
Arbuck, S. ;
Gwyther, S. ;
Mooney, M. ;
Rubinstein, L. ;
Shankar, L. ;
Dodd, L. ;
Kaplan, R. ;
Lacombe, D. ;
Verweij, J. .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (02) :228-247
[2]   Scintigraphic pattern of skeletal involvement of Waldenstrom macroglobulinemia [J].
Elmonayeri, Magda S. ;
Elgazzar, Abdelhamid H. .
CLINICAL NUCLEAR MEDICINE, 2008, 33 (08) :585-586
[3]   Prognostic model for disease-specific and overall mortality in newly diagnosed symptomatic patients with Waldenstrom macroglobulinaemia [J].
Ghobrial, IM ;
Fonseca, R ;
Gertz, MA ;
Plevak, MF ;
Larson, DR ;
Therneau, TM ;
Wolf, RC ;
Hoffmann, RJ ;
Lust, JA ;
Witzig, TE ;
Lacy, MQ ;
Dispenzieri, A ;
Rajkumar, SV ;
Zeldenrust, SR ;
Greipp, PR ;
Kyle, RA .
BRITISH JOURNAL OF HAEMATOLOGY, 2006, 133 (02) :158-164
[4]   Waldenstrom macroglobulinaemia [J].
Ghobrial, IM ;
Gertz, MA ;
Fonseca, R .
LANCET ONCOLOGY, 2003, 4 (11) :679-685
[5]   Waldenström macroglobulinemia [J].
Ghobrial I.M. ;
Witzig T.E. .
Current Treatment Options in Oncology, 2004, 5 (3) :239-247
[6]   Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) for the staging of low-grade non-Hodgkin's lymphoma (NHL) [J].
Jerusalem, G ;
Beguin, Y ;
Najjar, F ;
Hustinx, R ;
Fassotte, MF ;
Rigo, P ;
Fillet, G .
ANNALS OF ONCOLOGY, 2001, 12 (06) :825-830
[7]   Use of positron emission tomography for response assessment of lymphoma: Consensus of the Imaging Subcommittee of International Harmonization Project in lymphoma [J].
Juweid, Malik E. ;
Stroobants, Sigrid ;
Hoekstra, Otto S. ;
Mottaghy, Felix M. ;
Dietlein, Markus ;
Guermazi, Ali ;
Wiseman, Gregory A. ;
Kostakoglu, Lale ;
Scheidhauer, Klemens ;
Buck, Andreas ;
Naumann, Ralph ;
Spaepen, Karoline ;
Hicks, Rodney J. ;
Weber, Wolfgang A. ;
Reske, Sven N. ;
Schwaiger, Markus ;
Schwartz, Lawrence H. ;
Zijlstra, Josee M. ;
Siegel, Barry A. ;
Cheson, Bruce D. .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :571-578
[8]   Update on recommendations for assessing response from the Third International Workshop on Waldenstrom's Macroglobulinemia [J].
Kimby, Eva ;
Treon, Steven P. ;
Anagnostopoulos, Athanasios ;
Dimopoulos, Meletios ;
Garcia-Sanz, Ramon ;
Gertz, Morie A. ;
Johnson, Stephen ;
LeBlond, Veronique ;
Fermand, Jean-Paul ;
Maloney, David G. ;
Merlini, Giampaolo ;
Morel, Pierre ;
Morra, Enrica ;
Nichols, Gwen ;
Ocio, Enrique M. ;
Owen, Roger ;
Stone, Marvin ;
Blade, Joan .
CLINICAL LYMPHOMA & MYELOMA, 2006, 6 (05) :380-383
[9]   18-FDG-PET as a prognostic indicator in the treatment of aggressive non-Hodgkin's lymphoma-comparison with CT [J].
Mikhaeel, NG ;
Timothy, AR ;
O'Doherty, MJ ;
Hain, S ;
Maisey, MN .
LEUKEMIA & LYMPHOMA, 2000, 39 (5-6) :543-553
[10]   WALDENSTROM MACROGLOBULINEMIA - MR-IMAGING OF THE SPINE AND CT OF THE ABDOMEN AND PELVIS [J].
MOULOPOULOS, LA ;
DIMOPOULOS, MA ;
VARMA, DGK ;
MANNING, JT ;
JOHNSTON, DA ;
LEEDS, NE ;
LIBSHITZ, HI .
RADIOLOGY, 1993, 188 (03) :669-673