Heparan Sulfate Proteoglycans

被引：1014

作者：

Sarrazin, Stephane ^{[1
]}

Lamanna, William C. ^{[1
]}

Esko, Jeffrey D. ^{[1
]}

机构：

[1] Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2011年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

FIBROBLAST-GROWTH-FACTOR; GLOMERULAR-BASEMENT-MEMBRANE; EMBRYONIC STEM-CELLS; LEUKOCYTE-ENDOTHELIAL INTERACTIONS; PROTEIN-LOSING ENTEROPATHY; MICE LACKING; L-SELECTIN; IN-VIVO; SERGLYCIN PROTEOGLYCAN; SYNDECAN-1; ECTODOMAIN;

D O I：

10.1101/cshperspect.a004952

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although fewin number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.

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页码：1 / 33

页数：33

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