Two New Phenolic Compounds from the Rhizomes of Gastrodia elata BLUME

被引：13

作者：

Han, Ah-Reum ^{[1
]}

Shin, Hyun Ji ^{[1
]}

Jeon, Ha Rim ^{[1
]}

Lee, Je-Hyun ^{[2
]}

Lee, Dongho ^{[3
]}

Seo, Eun-Kyoung ^{[1
]}

机构：

[1] Ewha Womans Univ, Ctr Cell Signaling & Drug Discovery Res, Coll Pharm, Seoul 120750, South Korea

[2] Dongguk Univ, Dept Korean Med, Geongju 780714, South Korea

[3] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136713, South Korea

来源：

HELVETICA CHIMICA ACTA | 2011年 / 94卷 / 07期

关键词：

HIPPOCAMPUS; ACID; EXTRACTS; BRAIN; ETHER; CELLS; B1;

D O I：

10.1002/hlca.201000425

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phytochemical investigation of the rhizomes of Gastrodia elata BLUME (Orchidaceae) led to the isolation and identification of twelve compounds, including two new phenolic compounds, 4-hydroxybenzyl vanillyl ether (=4-{[(4-hydroxyphenyl)methoxy]methyl]-2-methoxyphenol; 1) and 4-{[4-[4-(methoxymethyl)phenoxy]benzyl}oxy}benzyl methyl ether (=1-[4-(methoxymethyl)phenoxy]-4-{[4-(methoxymethyl)phenoxy]methyl}benzene; 2). The structures of 1 and 2 were elucidated by spectroscopic data analysis including 1D- and 2D-NMR experiments.

引用

页码：1310 / 1314

页数：5

共 21 条

[1] Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells [J].

An, Hua ;

Kim, In Su ;

Koppula, Sushruta ;

Kim, Byung Wook ;

Park, Pyo Jam ;

Lim, Beong Ou ;

Choi, Wahn Soo ;

Lee, Kwang Ho ;

Choi, Dong Kug .

JOURNAL OF ETHNOPHARMACOLOGY, 2010, 130 (02) :290-298

[2] Gastrodin decreases immunoreactivities of γ-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils [J].

An, SJ ;

Park, SK ;

Hwang, IK ;

Choi, SY ;

Kim, SK ;

Kwon, OS ;

Jung, SJ ;

Baek, NI ;

Lee, HY ;

Won, MH ;

Kang, TC .

JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 71 (04) :534-543

[3] Biotransformation of bisphenol F by human and rat liver subcellular fractions [J].

Cabaton, Nicolas ;

Zalko, Daniel ;

Rathahao, Estelle ;

Canlet, Cecile ;

Delous, Georges ;

Chagnon, Marie-Christine ;

Cravedi, Jean-Pierre ;

Perdu, Elisabeth .

TOXICOLOGY IN VITRO, 2008, 22 (07) :1697-1704

[4] The antidepressant effect of Gastrodia elata B1. on the forced-swimming test in rats [J].

Chen, Pei-Ju ;

Hsieh, Ching-Liang ;

Su, Kuan-Pin ;

Hou, Yu-Chi ;

Chiang, Hsiu-Mei ;

Lin, I-Hsin ;

Sheen, Lee-Yan .

AMERICAN JOURNAL OF CHINESE MEDICINE, 2008, 36 (01) :95-106

[5] 4-hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain [J].

Ha, JH ;

Lee, DU ;

Lee, JT ;

Kim, JS ;

Yong, CS ;

Kim, JA ;

Ha, JS ;

Huh, K .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) :329-333

[6] Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation [J].

Hayashi, J ;

Sekine, T ;

Deguchi, S ;

Lin, Q ;

Horie, S ;

Tsuchiya, S ;

Yano, S ;

Watanabe, K ;

Ikegami, F .

PHYTOCHEMISTRY, 2002, 59 (05) :513-519

[7] Anti-Inflammatory Effect of Gastrodia elata Rhizome in Human Umbilical Vein Endothelial Cells [J].

Hwang, Sun Mi ;

Lee, Yun Jung ;

Kang, Dae Gill ;

Lee, Ho Sub .

AMERICAN JOURNAL OF CHINESE MEDICINE, 2009, 37 (02) :395-406

[8] Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl [J].

Jang, Young Woon ;

Lee, Ji Yun ;

Kim, Chang Jong .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2010, 10 (02) :147-154

[9] Anxiolytic-Like effects of Gastrodia elata and its phenolic constituents in mice [J].

Jung, JW ;

Yoon, BH ;

Oh, HR ;

Ahn, JH ;

Kim, SY ;

Park, SY ;

Ryu, JF .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (02) :261-265

[10] Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus [J].

Kim, HJ ;

Moon, KD ;

Oh, SY ;

Kim, SP ;

Lee, SR .

NEUROSCIENCE LETTERS, 2001, 314 (1-2) :65-68

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