Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation

被引：274
|
作者：
Wang, Yi-Feng [1 ]
Toh, Kah Kah [1 ]
Lee, Jian-Yuan [1 ]
Chiba, Shunsuke [1 ]
机构：
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 26期
关键词：
alkynes; azides; copper; heterocycles; rhodium; CATALYZED OXIDATIVE COUPLING/CYCLIZATION; FREE-RADICAL REACTIONS; BOND FORMATION; CARBON-HYDROGEN; FUNCTIONALIZATION; BENZAMIDES; COMPLEXES; PYRROLES; IMINES; RU;
D O I：
10.1002/anie.201101009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Catalysts in a relay: A synthetic method for delivering highly substituted isoquinolines has been developed (see scheme; Cp =C5Me5, DMF=N,N-dimethylformamide, TEMPO=2,2,6,6-tetramethylpiperidine-1-oxyl). A preliminary mechanistic study showed that the rhodium and copper cooperate synergistically in the multistep sequence. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5927 / 5931
页数：5
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