Organocatalytic asymmetric intramolecular aza-Henry reaction: facile synthesis of trans-2,3-disubstituted tetrahydroquinolines

被引：9
作者：
Maity, Rajendra [1 ]
Pan, Subhas Chandra [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 24期
关键词：
FREE-RADICAL SCAVENGERS; FUNCTIONALIZED TETRAHYDROQUINOLINES; TRANSFER HYDROGENATION; QUINOLINES; ACTIVATION; CATALYSIS; INDOLINES; LIGANDS; CLOSURE; ACCESS;
D O I：
10.1039/c5ob00795j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantio-and diastereoselective organocatalytic intramolecular aza-Henry (nitro-Mannich) reaction has been developed. The trans-2-aryl-3-nitro-tetrahydroquinoline products are obtained in high yields and in good enantioselectivities with a bifunctional tertiary amine-thiourea catalyst. Excellent enantioselectivities were obtained after single recrystallization of some products.
引用
收藏
页码：6825 / 6831
页数：7
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