SAR650984, a humanized anti-CD38 antibody potently modulates intracellular and extracellular nucleotide levels of cancer cells

被引:1
|
作者
Zhang, Bailin [1 ]
Yang, Guang [1 ]
Dai, Shujia [1 ]
He, Tim [1 ]
Simard, Daniel [1 ]
Song, Zhili [1 ]
Licht, Stuart [1 ]
Adrian, Francisco [1 ]
Cheng, Hong [1 ]
Cai, Ti [1 ]
机构
[1] Sanofi, Cambridge, MA USA
关键词
D O I
10.1158/1538-7445.AM2014-5468
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5468
引用
收藏
页数:1
相关论文
共 50 条
  • [1] SAR650984, A HUMANIZED ANTI-CD38 ANTIBODY, POTENTLY TARGETS CANCER CELLS THROUGH MULTIPLE MECHANISMS
    Cai, T.
    Zhang, B.
    Yang, G.
    Song, Z.
    Dai, S.
    He, T.
    Simard, D.
    Licht, S.
    Adrian, F.
    Cheng, H.
    Corzo, K.
    HAEMATOLOGICA, 2014, 99 : 355 - 355
  • [2] Broad spectrum of antitumor activity of SAR650984, a humanized anti-CD38 antibody targeting hematological malignancies
    Lejeune, Pascale
    Deckert, Jutta
    Mayo, Michele
    Whiteman, Kathy
    Johnson, Starrla
    Guyre, Cheryl
    Blanc, Veronique
    Park, Peter
    Lutz, Robert
    Bissery, Marie-Christine
    Vrignaud, Patricia
    CANCER RESEARCH, 2009, 69
  • [3] In vivo therapeutic synergy of SAR650984, a humanized anti-CD38 antibody, in combination with melphalan in a multiple myeloma xenograft.
    Lejeune, Pascale
    Blanc, Veronique
    Courta, Jacqueline
    Egile, Coumaran
    Vrignaud, Patricia
    Deckert, Jutta
    Park, Peter
    Bissery, Marie-Christine
    CANCER RESEARCH, 2009, 69
  • [4] All-trans retinoic acid enhances the effector functions of the anti-CD38 antibody SAR650984
    Bush, Lucas
    Harper, David
    Greco, Rita
    Song, Zhili
    Yang, Guang
    Adrian, Francisco
    CANCER RESEARCH, 2015, 75
  • [5] SAR650984: Characterization of a potent phase I humanized anti-CD38 antibody for the treatment of multiple myeloma and other hematologic malignancies.
    Wetzel, Marie-Cecile
    Nicolazzi, Celine
    Vallee, Francois
    Deckert, Jutta
    Dumontet, Charles
    Plesa, Adriana
    Kannt, Aimo
    Mikol, Vincent
    Chiron, Marielle
    Vincent, Loic
    Blanc, Veronique
    CANCER RESEARCH, 2013, 73 (08)
  • [6] SAR650984, an anti-CD38 antibody, shows anti-tumor activity in a preclinical model of multiple myeloma.
    Hann, Byron
    Cai, T. I.
    Wang, Donghui
    Hom, Yun-Kit
    Aftab, Blake T.
    Martin, Tom
    Wolf, Jeffrey
    CANCER RESEARCH, 2013, 73 (08)
  • [7] SAR650984, a humanized anti-CD38 antibody, shows potent in vitro activity by multiple mechanisms against various hematologic tumor cell lines.
    Deckert, Jutta
    Yi, Yong
    Chicklas, Sharon
    Mayo, Michele
    Chittenden, Thomas
    Park, Peter
    CANCER RESEARCH, 2009, 69
  • [8] A first-in-human phase I study of SAR650984, a humanized anti-CD38 antibody in patients with CD38+hematological malignancies: Preliminary PK and PD results of escalation phase
    Ozoux, Marie-Laure L.
    Guillemin, Helene
    Pascual, Marie-Helene H.
    Cartot-Cotton, Sylvaine
    Veyrat-Follet, Christine
    Valente, Delphine
    Moulard, Maxime
    Mauriac, Christine
    Deslandes, Antoine
    Semiond, Dorothee
    CANCER RESEARCH, 2014, 74 (19)
  • [9] SAR650984: A Potent Anti-CD38 Therapeutic Antibody with Three Mechanisms of Action (Apoptosis, ADCC, CDC) for Hematological Malignancies.
    Park, Peter U.
    Blanc, Veronique
    Deckert, Jutta
    Lejeune, Pascale
    Bartle, Laura M.
    Skaletskaya, Anna
    Mayo, Michele F.
    Zhang, Chonghui
    Wetzel, Marie-Cecile
    Tavares, Daniel J.
    Lutz, Robert J.
    Chittenden, Thomas
    Bissery, Marie-Christine
    Lambert, John M.
    Goldmacher, Victor S.
    BLOOD, 2008, 112 (11) : 951 - 951
  • [10] SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma
    An, Gang
    Jiang, Hua
    Acharya, Chirag
    Zhong, Mike Y.
    Cai, Ti
    Yang, Guang
    Song, Zhili
    Theilhaber, Joachim
    Adrian, Francisco
    Tai, Yu-Tzu
    Anderson, Kenneth C.
    BLOOD, 2014, 124 (21)