A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

被引：38

作者：

Friscic, Tomislav ^{[1
]}

Halasz, Ivan ^{[2
]}

Strobridge, Fiona C. ^{[1
]}

Dinnebier, Robert E. ^{[2
]}

Stein, Robin S. ^{[3
]}

Fabian, Laszlo ^{[4
]}

Curfs, Caroline ^{[5
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Max Planck Inst Solid State Res, D-70569 Stuttgart, Germany

[3] Bruker UK Ltd, Coventry, W Midlands, England

[4] Univ Coll Cork, Dept Chem, Cork, Ireland

[5] ESRF ID31, Grenoble, France

来源：

CRYSTENGCOMM | 2011年 / 13卷 / 09期

关键词：

IMPROVING MECHANICAL-PROPERTIES; COCRYSTAL FORMATION; COPPER-COMPLEXES; SODIUM NAPROXEN; DRUG; DIFFRACTION; IBUPROFEN; SOLIDS; REACTIVITY; CHEMISTRY;

D O I：

10.1039/c0ce00894j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Variation of water content in liquid-assisted grinding was utilised to mechanochemically screen for different hydrated forms of magnesium naproxen directly from a mixture of magnesium oxide and naproxen. Structure determination from powder and single crystal X-ray diffraction data, supported by solid-state NMR and synchrotron radiation diffraction experiments, revealed a monohydrate coordination polymer, a discrete tetrahydrate complex, and provided a preliminary structural model for a highly hydrated salt.

引用

页码：3125 / 3129

页数：5

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