Spinal fusion surgery: animal models for tissue-engineered bone constructs

被引：25

作者：

Khan, SN

Lane, JM

机构：

[1] Cornell Univ, Weill Med Coll, Hosp Special Surg, Osteoporosis Prevent Ctr,Metab Bone Dis Serv, New York, NY 10021 USA

[2] Hosp Special Surg, Spinal Surg Serv, New York, NY 10021 USA

来源：

BIOMATERIALS | 2004年 / 25卷 / 09期

关键词：

spinal fusion; animal models; fusion parameters;

D O I：

10.1016/S0142-9612(03)00491-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Animal models have been used extensively to investigate the biology of fracture healing and spinal fusion. The goal of each spinal fusion model is to try and reproduce the correct sequence of events during osseous healing in humans. Animal models allow us the capability of dialing in fusion rates and fusion parameters depending upon the study conditions. These models have become invaluable in assessing the clinical potential of emerging technologies such as recombinant growth factors and gene therapy. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1475 / 1485

页数：11

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