Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase

被引：38

作者：

Brenner, David A. ^{[1
]}

Seki, Ekihiro ^{[1
]}

Taura, Kojiro ^{[1
]}

Kisseleva, Tatiana ^{[1
]}

Deminicis, Samuele ^{[1
]}

Iwaisako, Keiko ^{[1
]}

Inokuchi, Sayaka ^{[1
]}

Schnabl, Bernd ^{[1
]}

Oesterreicher, Christopher H. ^{[1
]}

Paik, Yong H. ^{[1
]}

Miura, Kouichi ^{[1
]}

Kodama, Yuzo ^{[1
]}

机构：

[1] UC San Diego Hlth Sci, Dept Med, La Jolla, CA 92093 USA

来源：

HEPATOLOGY RESEARCH | 2011年 / 41卷 / 07期

关键词：

fibrosis; Jun N-terminal kinase; liver; reactive oxygen species; Toll-like receptor;

D O I：

10.1111/j.1872-034X.2011.00814.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic steatohepatitis (NASH) represents the progression of hepatic steatosis to streatohepatitis, fibrosis and cirrhosis. Three signaling pathways have been associated with this progression; Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. This review will describe how activation of these three pathways is required for development of fibrosis in murine models of NASH. The three pathways are related and synergistic through intracellular cross-talk. Disruption of any of these pathways may inhibit NASH-induced fibrosis and are potential targets for therapeutic intervention.

引用

页码：683 / 686

页数：4

共 3 条

[1] Role and Cellular Source of Nicotinamide Adenine Dinucleotide Phosphate Oxidase in Hepatic Fibrosis
De Minicis, Samuele
Seki, Ekihiro
Paik, Yong-Han
Oesterreicher, Christoph H.
Kodama, Yuzo
Kluwe, Johannes
Torozzi, Luciano
Miyai, Katsumi
Benedetti, Antonio
Schwabe, Robert F.
Brenner, David A.
[J]. HEPATOLOGY, 2010, 52 (04) : 1420 - 1430
[2] c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice
Kodama, Yuzo
Kisseleva, Tatiana
Iwaisako, Keiko
Miura, Kouichi
Taura, Kojiro
De Minicis, Samuele
Osterreicher, Christoph H.
Schnabl, Bernd
Seki, Ekihiro
Brenner, David A.
[J]. GASTROENTEROLOGY, 2009, 137 (04) : 1467 - 1477
[3] Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
Miura, Kouichi
Kodama, Yuzo
Inokuchi, Sayaka
Schnabl, Bernd
Aoyama, Tomonori
Ohnishi, Hirohide
Olefsky, Jerrold M.
Brenner, David A.
Seki, Ekihiro
[J]. GASTROENTEROLOGY, 2010, 139 (01) : 323 - U453

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