Circulating Tumor Cells in Hepatocellular Carcinoma: A Comprehensive Review and Critical Appraisal

被引:26
作者
Espejo-Cruz, Maria Lola [1 ]
Gonzalez-Rubio, Sandra [1 ]
Zamora-Olaya, Javier [1 ,2 ]
Amado-Torres, Victor [1 ,2 ]
Alejandre, Rafael [1 ,2 ]
Sanchez-Frias, Marina [3 ]
Ciria, Ruben [1 ,4 ]
De la Mata, Manuel [1 ,2 ,5 ]
Rodriguez-Peralvarez, Manuel [1 ,2 ,5 ]
Ferrin, Gustavo [1 ,5 ]
机构
[1] Univ Cordoba, Maimonides Inst Biomed Res IMIBIC, Avda Menendez Pidal S-N, Cordoba 14004, Spain
[2] Reina Sofia Univ Hosp, Dept Hepatol & Liver Transplantat, Avda Menendez Pidal S-N, Cordoba 14004, Spain
[3] Reina Sofia Univ Hosp, Dept Pathol, Avda Menendez Pidal S-N, Cordoba 14004, Spain
[4] Reina Sofia Univ Hosp, Dept Hepatobiliary Surg & Liver Transplantat, Cordoba 14004, Spain
[5] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain
关键词
hepatocellular carcinoma; liquid biopsy; circulating tumor cells; dynamic changes; therapeutic target; CANCER STEM-CELLS; MESENCHYMAL TRANSITION; LIVER-TRANSPLANTATION; LIQUID BIOPSY; MICROVASCULAR INVASION; CLINICAL-SIGNIFICANCE; PERIPHERAL-BLOOD; EARLY RECURRENCE; METASTASIS; EPCAM;
D O I
10.3390/ijms222313073
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hepatocellular carcinoma (HCC) is the fifth most common neoplasm and a major cause of cancer-related death worldwide. There is no ideal biomarker allowing early diagnosis of HCC and tumor surveillance in patients receiving therapy. Liquid biopsy, and particularly circulating tumor cells (CTCs), have emerged as a useful tool for diagnosis and monitoring therapeutic responses in different tumors. In the present manuscript, we evaluate the current evidence supporting the quantitative and qualitative assessment of CTCs as potential biomarkers of HCC, as well as technical aspects related to isolation, identification, and classification of CTCs. Although the dynamic assessment of CTCs in patients with HCC may aid the decision-making process, there are still many uncertainties and technical caveats to be solved before this methodology has a true impact on clinical practice guidelines. More studies are needed to identify the optimal combination of surface markers, to increase the efficiency of ex-vivo expansion of CTCs, or even to target CTCs as a potential therapeutic strategy to prevent HCC recurrence after surgery or to hamper tumor progression and extrahepatic spreading.
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页数:19
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