Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

被引：47
作者：
Ghani, Sherif B. Abdel [1 ]
Weaver, Louise [2 ]
Zidan, H. Zidan [3 ]
Ali, Hussein M. [4 ]
Keevil, C. William [2 ]
Brown, Richard C. D. [1 ]
机构：
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Sch Biol Sci, Environm Hlthcare Unit, Southampton SO16 7PX, Hants, England
[3] Ain Shams Univ, Fac Agr, Dept Plant Protect, Cairo, Egypt
[4] Ain Shams Univ, Fac Agr, Dept Agr Biochem, Cairo, Egypt
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期
关键词：
antibacterial; antifungal; flavonoids;
D O I：
10.1016/j.bmcl.2007.11.081
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eleven flavonoid derivatives were synthesised using a modified Baker-Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：518 / 522
页数：5
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