Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Vesicles and Their Influence on the Heart's Vulnerability to Ischemia-Reperfusion Injury

被引:6
作者
Majka, Milosz [1 ]
Kleibert, Marcin [1 ]
Wojciechowska, Malgorzata [1 ,2 ]
机构
[1] Med Univ Warsaw, Dept Expt & Clin Physiol, Lab Ctr Preclin Res, Banacha 1b, PL-02097 Warsaw, Poland
[2] Independent Publ Specialist Western Hosp John Pau, Invas Cardiol Unit, Daleka 11, PL-05825 Grodzisk Mazowiecki, Poland
关键词
extracellular vesicles; exosomes; microvesicles; ischemia-reperfusion injury; myocardial infarction; diabetes; obesity; smoking; physical activity; miRNA; ENDOTHELIAL PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; TYPE-2; DIABETES-MELLITUS; MESENCHYMAL STEM-CELLS; INDUCED CARDIOMYOCYTE APOPTOSIS; PLATELET-DERIVED MICROPARTICLES; ISCHEMIA/REPERFUSION INJURY; CIRCULATING MICRORNAS; OXIDATIVE STRESS; DOWN-REGULATION;
D O I
10.3390/cells10123331
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The majority of cardiovascular deaths are associated with acute coronary syndrome, especially ST-elevation myocardial infarction. Therapeutic reperfusion alone can contribute up to 40 percent of total infarct size following coronary artery occlusion, which is called ischemia-reperfusion injury (IRI). Its size depends on many factors, including the main risk factors of cardiovascular mortality, such as age, sex, systolic blood pressure, smoking, and total cholesterol level as well as obesity, diabetes, and physical effort. Extracellular vesicles (EVs) are membrane-coated particles released by every type of cell, which can carry content that affects the functioning of other tissues. Their role is essential in the communication between healthy and dysfunctional cells. In this article, data on the variability of the content of EVs in patients with the most prevalent cardiovascular risk factors is presented, and their influence on IRI is discussed.
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页数:33
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