Histone lactylation: epigenetic mark of glycolytic switch

被引：85

作者：

Dai, Xiaofeng ^{[1
]}

Lv, Xinyu ^{[1
]}

Thompson, Erik W. ^{[2
,3
]}

Ostrikov, Kostya ^{[4
]}

机构：

[1] Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China

[2] Queensland Univ Technol, Sch Biomed Sci, Fac Hlth, Brisbane, Qld 4059, Australia

[3] Translat Res Inst, Woolloongabba, Qld 4102, Australia

[4] Queensland Univ Technol, Sch Chem & Phys, Fac Sci, Brisbane, Qld 4059, Australia

来源：

TRENDS IN GENETICS | 2022年 / 38卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tig.2021.09.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Y Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel therapeutic opportunities against cancers.

引用

页码：124 / 127

页数：4