X-ray fluorescence elemental mapping and microscopy to follow hepatic disposition of a Gd-based magnetic resonance imaging contrast agent

被引：13

作者：

Delfino, Riccarda ^{[2
]}

Altissimo, Matteo ^{[9
,10
]}

Menk, Ralf Hendrik ^{[4
]}

Alberti, Roberto ^{[5
,7
]}

Klatka, Tomasz ^{[5
,7
]}

Frizzi, Tommaso ^{[5
,7
,8
]}

Longoni, Antonio ^{[5
,7
]}

Salome, Murielle ^{[3
,5
]}

Tromba, Giuliana ^{[4
]}

Arfelli, Fulvia ^{[3
,5
]}

Clai, Milan ^{[6
]}

Vaccari, Lisa ^{[4
]}

Lorusso, Vito

Tiribelli, Claudio

Pascolo, Lorella ^{[1
,4
]}

机构：

[1] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy

[2] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy

[3] Univ Trieste, Dept Phys, I-34127 Trieste, Italy

[4] Synchrotron Trieste SCpA, Trieste, Italy

[5] Ist Nazl Fis Nucl, Milan, Italy

[6] Univ Hosp Trieste, Trieste, Italy

[7] Politecn Milan, Dept Elect & Informat, Milan, Italy

[8] XGLab Srl, Milan, Italy

[9] CSIRO Mat Sci & Engn, Melbourne, Vic, Australia

[10] European Synchrotron Radiat Facil, F-38043 Grenoble, France

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2011年 / 38卷 / 12期

关键词：

chemical imaging; liver; magnetic resonance imaging contrast agents; X-ray fluorescence; MONOLITHIC ARRAY; IN-VITRO; LIVER; GADOLINIUM; EXPRESSION; TRANSPORT; MICROPROBE; SPECIATION; B22956/1; CELLS;

D O I：

10.1111/j.1440-1681.2011.05618.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Spatially resolved X-ray fluorescence (XRF) spectroscopy with synchrotron radiation is a technique that allows imaging and quantification of chemical elements in biological specimens with high sensitivity. In the present study, we applied XRF techniques at a macro and micro level to carry out drug distribution studies on ex vivo models to confirm the hepatobiliary disposition of the Gd-based magnetic resonance imaging contrast agent B22956/1.

引用

页码：834 / 845

页数：12

共 38 条

[1] USB 2.0 data acquisition system for high-speed X-ray elemental mapping [J].

Alberti, R. ;

Guazzoni, C. ;

Klatka, T. .

JOURNAL OF INSTRUMENTATION, 2008, 3

[2] Elemental mapping by means of an ultra-fast XRF spectrometer based on a novel high-performance monolithic array of Silicon Drift Detectors [J].

Alberti, R. ;

Florini, C. ;

Guazzoni, C. ;

Klatka, T. ;

Longoni, A. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2007, 580 (02) :1004-1007

[3] Performance evaluation of an advanced XRF elemental mapping system featuring a novel ring-shaped monolithic array of silicon drift detectors [J].

Alberti, R. ;

Buzzetti, S. ;

Fiorini, C. ;

Guazzoni, C. ;

Klatka, T. ;

Lechner, P. ;

Longoni, A. ;

Strueder, L. .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2007, 54 (03) :751-757

[4]

Alberti R, 2006, IEEE NUCL SCI CONF R, P1528

[5] Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury [J].

Aleksunes, LM ;

Scheffer, GL ;

Jakowski, AB ;

Pruimboom-Brees, IM ;

Manautou, JE .

TOXICOLOGICAL SCIENCES, 2006, 89 (02) :370-379

[6] Tracing exogenous Gd and its effects in single Chang cells [J].

Altissimo, Matteo ;

Pascolo, Lorella ;

Delfino, Riccarda ;

Salome, Murielle ;

Lorusso, Vito .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2010, 619 (1-3) :348-352

[7] Conjugates of gadolinium complexes to bile acids as hepatocyte-directed contrast agents for magnetic resonance Imaging [J].

Anelli, PL ;

Lattuada, L ;

Lorusso, V ;

Lux, G ;

Morisetti, A ;

Morosini, P ;

Serleti, M ;

Uggeri, F .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (14) :3629-3641

[8] Low-dose phase contrast x-ray medical imaging [J].

Arfelli, F ;

Assante, M ;

Bonvicini, V ;

Bravin, A ;

Cantatore, G ;

Castelli, E ;

Dalla Palma, L ;

Di Michiel, M ;

Longo, R ;

Olivo, A ;

Pani, S ;

Pontoni, D ;

Poropat, P ;

Prest, M ;

Rashevsky, A ;

Tromba, G ;

Vacchi, A ;

Vallazza, E ;

Zanconati, F .

PHYSICS IN MEDICINE AND BIOLOGY, 1998, 43 (10) :2845-2852

[9]

BOWLER JM, 1995, J MEMBRANE BIOL, V145, P175

[10] Preclinical profile and clinical potential of gadocoletic acid trisodium salt (B22956/1), a new intravascular contrast medium for MRI [J].

Cavagna, FM ;

Lorusso, V ;

Anelli, PL ;

Maggioni, F ;

de Haën, C .

ACADEMIC RADIOLOGY, 2002, 9 :S491-S494

← 1 2 3 4 →