Alpha-1 Antitrypsin: A Potent Anti-Inflammatory and Potential Novel Therapeutic Agent

被引：108

作者：

Bergin, David A. ^{[1
]}

Hurley, Killian ^{[1
]}

McElvaney, Noel G. ^{[1
]}

Reeves, Emer P. ^{[1
]}

机构：

[1] Beaumont Hosp, Resp Res Div, Dept Med, Royal Coll Surg Ireland,Educ & Res Ctr, Dublin 9, Ireland

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2012年 / 60卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

Alpha-1; antitrypsin; Innate immune cells; Alpha-1 antitrypsin deficiency; Replacement therapy; NECROSIS-FACTOR-ALPHA; ALPHA(1)-ANTITRYPSIN AUGMENTATION THERAPY; NEUTROPHIL ELASTASE INHIBITOR; ISLET ALLOGRAFT SURVIVAL; ACUTE LUNG INFLAMMATION; CYSTIC-FIBROSIS; ALPHA(1)-PROTEINASE INHIBITOR; ALPHA-1-PROTEINASE INHIBITOR; HUMAN MONOCYTES; ANTITRYPSIN DEFICIENCY;

D O I：

10.1007/s00005-012-0162-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alpha-1 antitrypsin (AAT) has long been thought of as an important anti-protease in the lung where it is known to decrease the destructive effects of major proteases such as neutrophil elastase. In recent years, the perception of this protein in this simple one dimensional capacity as an antiprotease has evolved and it is now recognised that AAT has significant anti-inflammatory properties affecting a wide range of inflammatory cells, leading to its potential therapeutic use in a number of important diseases. This present review aims to discuss the described anti-inflammatory actions of AAT in modulating key immune cell functions, delineate known signalling pathways and specifically to identify the models of disease in which AAT has been shown to be effective as a therapy.

引用

页码：81 / 97

页数：17

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