Relationship between quality of life and behavioural disorders in children with persistent asthma: a Multiple Indicators Multiple Causes (MIMIC) model

被引：37

作者：

Montalbano, Laura ^{[1
]}

Ferrante, Giuliana ^{[2
]}

Montella, Silvia ^{[3
]}

Cilluffo, Giovanna ^{[1
]}

Di Marco, Antonio ^{[4
]}

Bozzetto, Sara ^{[5
]}

Di Palmo, Emanuela ^{[6
]}

Licari, Amelia ^{[7
]}

Leonardi, Lucia ^{[8
]}

Caldarelli, Valeria ^{[9
]}

Ghezzi, Michele ^{[10
]}

La Grutta, Stefania ^{[1
]}

Rusconi, Franca ^{[11
]}

机构：

[1] Natl Res Council Italy, Inst Res & Biomed Innovat, IRIB, Via Ugo La Malfa 153, I-90146 Palermo, Italy

[2] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Special, Palermo, Italy

[3] Univ Naples Federico II, Dept Translat Med Sci, Via Sergio Pansini 5, I-80131 Naples, Italy

[4] Acad Dept Pediat Hosp Bambino Gesu, Pediat Pulmonol & Sleep & Long Term Ventilat Unit, Piazza S Onofrio 4, I-00165 Rome, Italy

[5] Univ Padua, Dept Womens & Childrens Hlth, Div Emergency Med, Padua, Italy

[6] Univ Bologna, Dept Med & Surg Sci, Pediat Unit, I-40138 Bologna, Italy

[7] Univ Pavia, Fdn IRCCS Policlin San Matteo, Pediat Clin, Piazzale Golgi 19, I-27100 Pavia, Italy

[8] Sapienza Univ Rome, Dept Paediat, Rome, Italy

[9] IRCCS, Azienda USL, Dept Obstet Gynecol & Pediat, Pediat Unit, Viale Risorgimento 80, I-42123 Reggio Emilia, Italy

[10] Univ Milan, Dept Pediat, Osped Bambini, Milan, Italy

[11] Anna Meyer Childrens Univ Hosp, Unit Epidemiol, Viale Pieraccini 24, I-50139 Florence, Italy

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

HEALTH; SEVERITY;

D O I：

10.1038/s41598-020-62264-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Knowledge on multiple interdependences between quality of life (QoL) and behavioural problems in relation to asthma severity and control is undetermined.T he aims of the study were: (i) to assess the relationship of QoL and behavioural problems with asthma severity and control (ii) to predict children's "abnormal/borderline" status with variation in QoL. For these purposes a multicenter case-control study on 47 Severe Asthma (SA) and 94 Moderate Asthma (MA) children was performed. The MIMIC approach was applied to investigate the effect of SA and non-controlled asthma (NC) on QoL and behavioural disorders. Logistic regression was used to estimate probabilities of having an "abnormal/borderline" status with variation in QoL. The MIMIC model showed that the magnitude of the effect of SA and NC was larger on QoL (beta = -0.37 and beta = -0.30, respectively) than on behavioural problems (beta = 0.27). With regards to the probability of having a borderline status, in MA a QoL of 1 returned a probability of 0.81, whereas in SA a QoL of 1 returned a probability of 0.89. In conclusion, SA children are highly affected by impaired QoL and behavioural problems. The MIMIC model allowed us to obtain a comprehensive assessment of QoL and behavioural problems with asthma severity and control.

引用

页数：9

共 39 条

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