Tolerance in liver transplantation

被引：33
作者：
Bishop, G. Alex [1 ,2 ,3 ]
Bertolino, Patrick D. [2 ,3 ]
Bowen, David G. [2 ,3 ]
McCaughan, Geoffrey W. [2 ,3 ]
机构：
[1] Royal Prince Alfred Hosp, Collaborat Transplantat Lab, Sydney, NSW 2006, Australia
[2] Univ Sydney, Sydney, NSW 2006, Australia
[3] Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Lab, Centenary Inst, Sydney, NSW 2006, Australia
来源：
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2012年 / 26卷 / 01期
基金：
英国医学研究理事会;
关键词：
Liver transplantation; Immune tolerance; Operational tolerance; Clinical transplantation; T-CELL-ACTIVATION; IMMUNOSUPPRESSION INHIBITS REJECTION; HEART-KIDNEY TRANSPLANTATION; RANDOMIZED CONTROLLED-TRIAL; LONG-TERM OUTCOMES; OPERATIONAL TOLERANCE; GRAFT ACCEPTANCE; PASSENGER LEUKOCYTES; PERIPHERAL-BLOOD; CLINICAL TRANSPLANTATION;
D O I：
10.1016/j.bpg.2012.01.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Operational tolerance (OT) in liver transplant patients occurs much more frequently than OT of other transplanted organs; however the rate of OT varies considerably with the centre and patient population. Rates of OT range from 15% of the total liver transplant (LTX) patient population down to less than 5%. This review examines the reports of liver OT and compares the factors that could contribute, to this variation. Multiple factors were examined, including the time from transplantation when weaning of immunosuppression (IS) was commenced, the rapidity of weaning, the contribution of maintenance and induction IS and the patient population transplanted. The approaches that might be used to increase the likelihood of OT are discussed and the approaches to monitoring OT in LTX patients are reviewed. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：73 / 84
页数：12
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