Neonatal diethylstilbestrol exposure disrupts female reproductive tract structure/function via both direct and indirect mechanisms in the hamster

被引:8
作者
Alwis, Imala D. [1 ]
Maroni, Dulce M. [1 ]
Hendry, Isabel R. [1 ]
Roy, Shyamal K. [2 ,3 ]
May, Jeffrey V. [1 ]
Leavitt, Wendell W. [1 ]
Hendry, William J. [1 ]
机构
[1] Wichita State Univ, Dept Biol Sci, Wichita, KS 67260 USA
[2] Univ Nebraska Med Ctr, Dept Obstet & Gynecol, Omaha, NE 68198 USA
[3] Univ Nebraska Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE 68198 USA
关键词
Female reproductive tract; Diethylstilbestrol; Endocrine disruption; Ovary; Hamster; POLYOVULAR FOLLICLES; ESTROGEN-RECEPTOR; CYCLIC HAMSTER; SYRIAN-HAMSTER; GENITAL-TRACT; PRENATAL EXPOSURE; TREATMENT ALTERS; ANIMAL-MODEL; CHEEK POUCH; IN-UTERO;
D O I
10.1016/j.reprotox.2011.09.006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We assessed neonatal diethylstilbestrol (DES)-induced disruption at various endocrine levels in the hamster. In particular, we used organ transplantation into the hamster cheek pouch to determine whether abnormalities observed in the post-pubertal ovary are due to: (a) a direct (early) mechanism or (b) an indirect (late) mechanism that involves altered development and function of the hypothalamus and/or pituitary. Of the various disruption endpoints and attributes assessed: (1) some were consistent with the direct mechanism (altered uterine and cervical dimensions/organization, ovarian polyovular follicles, vaginal hypospadius, endometrial hyperplasia/dysplasia); (2) some were consistent with the indirect mechanism (ovarian/oviductal salpingitis, cystic ovarian follicles); (3) some were consistent with a combination of the direct and indirect mechanisms (altered endocrine status); and (4) the mechanism(s) for one (lack of corpora lutea) was uncertain. This study also generated some surprising observations regarding vaginal estrous assessments as a means to monitor periodicity of ovarian function in the hamster. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:472 / 483
页数:12
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