Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1

被引:373
作者
Harmar, Anthony J. [1 ]
Fahrenkrug, Jan [2 ]
Gozes, Illana [3 ]
Laburthe, Marc [4 ]
May, Victor [5 ]
Pisegna, Joseph R. [6 ,7 ]
Vaudry, David [8 ]
Vaudry, Hubert
Waschek, James A. [9 ]
Said, Sami I. [10 ,11 ]
机构
[1] Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland
[2] Univ Copenhagen, Dept Clin Biochem, Copenhagen, Denmark
[3] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel
[4] Univ Paris 07, INSERM U773, Ctr Rech Biomed Bichat Beaujon CRB3, Paris, France
[5] Univ Vermont, Coll Med, Dept Anat & Neurobiol, Burlington, VT 05405 USA
[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
[7] VA Greater Los Angeles Healthcare Syst, Div Gastroenterol, Los Angeles, CA USA
[8] Univ Rouen, European Inst Peptide Res IFRMP23, Mont St Aignan, France
[9] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA
[10] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA
[11] SUNY Stony Brook, Grad Program Pharmacol, Stony Brook, NY 11794 USA
关键词
accessory proteins; agonists and antagonists; class B GPCR; PAC1; receptor; PACAP; signal transduction; splice variant; VIP; VPAC1; VPAC2; CEREBELLAR GRANULE NEURONS; PACAP TYPE-1 RECEPTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROTEIN-COUPLED RECEPTOR; DIFFERENTIAL SIGNAL-TRANSDUCTION; LONG-TERM POTENTIATION; IN-SITU HYBRIDIZATION; RAT ADRENAL-MEDULLA; INDUCED PHASE-SHIFT; MICE LACKING PACAP;
D O I
10.1111/j.1476-5381.2012.01871.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are members of a superfamily of structurally related peptide hormones that includes glucagon, glucagon-like peptides, secretin, gastric inhibitory peptide (GIP) and growth hormone-releasing hormone (GHRH). VIP and PACAP exert their actions through three GPCRs PAC1, VPAC1 and VPAC2 belonging to class B (also referred to as class II, or secretin receptor-like GPCRs). This family comprises receptors for all peptides structurally related to VIP and PACAP, and also receptors for parathyroid hormone, corticotropin-releasing factor, calcitonin and related peptides. PAC1 receptors are selective for PACAP, whereas VPAC1 and VPAC2 respond to both VIP and PACAP with high affinity. VIP and PACAP play diverse and important roles in the CNS, with functions in the control of circadian rhythms, learning and memory, anxiety and responses to stress and brain injury. Recent genetic studies also implicate the VPAC2 receptor in susceptibility to schizophrenia and the PAC1 receptor in post-traumatic stress disorder. In the periphery, VIP and PACAP play important roles in the control of immunity and inflammation, the control of pancreatic insulin secretion, the release of catecholamines from the adrenal medulla and as co-transmitters in autonomic and sensory neurons. This article, written by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) subcommittee on receptors for VIP and PACAP, confirms the existing nomenclature for these receptors and reviews our current understanding of their structure, pharmacology and functions and their likely physiological roles in health and disease. More detailed information has been incorporated into newly revised pages in the IUPHAR database ().
引用
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页码:4 / 17
页数:14
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