Plasma levels of stromal cell-derived factor-1 in patients with coronary artery disease: Effect of clinical presentation and cardiovascular risk factors

被引：32
作者：
Stellos, Konstantinos [1 ,2 ]
Ruf, Madlen [2 ]
Sopova, Kateryna [2 ]
Kilias, Antonios [2 ]
Rahmann, Angela [2 ]
Stamatelopoulos, Kimon [3 ]
Jorbenadze, Rezo [2 ]
Geisler, Tobias [2 ]
Gawaz, Meinrad [2 ]
Bigalke, Boris [2 ,4 ]
机构：
[1] Goethe Univ Frankfurt, Ctr Internal Med 3, Dept Cardiol, Frankfurt, Germany
[2] Univ Tubingen, Med Klin 3, Tubingen, Germany
[3] Univ Athens, Alexandra Hosp, Dept Clin Therapeut, GR-10679 Athens, Greece
[4] Kings Coll London, St Thomas Hosp, Rayne Inst, Div Imaging Sci & Biomed Engn, London WC2R 2LS, England
来源：
ATHEROSCLEROSIS | 2011年 / 219卷 / 02期
关键词：
Stromal cell derived factor 1; Acute myocardial infarction; Cardiovascular risk factors; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL PROGENITOR CELLS; CHEMOKINE SDF-1; CD34(+) CELLS; STEM-CELLS; G-CSF; MOBILIZATION; RECRUITMENT; CXCR4(+);
D O I：
10.1016/j.atherosclerosis.2011.09.022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To investigate the possible association of plasma levels of stromal cell-derived factor-1 (SDF-1; CXCL12) with clinical presentation of symptomatic coronary artery disease (CAD) and with cardiovascular risk factors. Methods: A cath lab cohort of 492 consecutive patients with symptomatic CAD were recruited. Blood for plasma-SDF-1 determination was taken at the time of heart catheterization before percutaneous coronary intervention. Results: Plasma-SDF-1 was significantly decreased in ST-elevation myocardial infarction (STEMI) compared to stable angina pectoris (SAP) or to non-ST-elevation myocardial infarction (NSTEMI) (SAP vs. NSTEMI vs. STEMI: [pg/ml]: mean +/- SD: 2110 +/- 562 vs. 2127 +/- 467 vs. 1834 +/- 377; P < 0.001) independent of cardiovascular therapy. A weak correlation was observed between cholesterol levels and plasma SDF-1 in the whole study population. Left ventricular function and diabetes mellitus associated with plasma SDF-1 levels in patients with NSTEMI, while among STEMI patients, those with hyperlipidemia presented with even further decreased SDF-1 levels. Conclusion: Plasma SDF-1 is significantly decreased in patients with STEMI, a fact which may reflect the importance of SDF-1 regulation in patients with acute myocardial infarction. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：913 / 916
页数：4
相关论文
共 15 条
[1]   Stromal cell-derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury [J].
Abbott, JD ;
Huang, Y ;
Liu, D ;
Hickey, R ;
Krause, DS ;
Giordano, FJ .
CIRCULATION, 2004, 110 (21) :3300-3305
[2]   The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].
Aiuti, A ;
Webb, IJ ;
Bleul, C ;
Springer, T ;
GutierrezRamos, JC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :111-120
[3]   Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy [J].
Askari, AT ;
Unzek, S ;
Popovic, ZB ;
Goldman, CK ;
Forudi, F ;
Kiedrowski, M ;
Rovner, A ;
Ellis, SG ;
Thomas, JD ;
DiCorleto, PE ;
Topol, EJ ;
Penn, MS .
LANCET, 2003, 362 (9385) :697-703
[4]   Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 [J].
Ceradini, DJ ;
Kulkarni, AR ;
Callaghan, MJ ;
Tepper, OM ;
Bastidas, N ;
Kleinman, ME ;
Capla, JM ;
Galiano, RD ;
Levine, JP ;
Gurtner, GC .
NATURE MEDICINE, 2004, 10 (08) :858-864
[5]   Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis [J].
Gomes, Ana L. ;
Carvalho, Tania ;
Serpa, Jacinta ;
Torre, Cheila ;
Dias, Sergio .
BLOOD, 2010, 115 (19) :3886-3894
[6]   Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes [J].
Jin, David K. ;
Shido, Koji ;
Kopp, Hans-Georg ;
Petit, Isabelle ;
Shmelkov, Sergey V. ;
Young, Lauren M. ;
Hooper, Andrea T. ;
Amano, Hideki ;
Avecilla, Scott T. ;
Heissig, Beate ;
Hattori, Koichi ;
Zhang, Fan ;
Hicklin, Daniel J. ;
Wu, Yan ;
Zhu, Zhenping ;
Dunn, Ashley ;
Salari, Hassan ;
Werb, Zena ;
Hackett, Neil R. ;
Crystal, Ronald G. ;
Lyden, David ;
Rafii, Shahin .
NATURE MEDICINE, 2006, 12 (05) :557-567
[7]   Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction [J].
Leone, Antonio Maria ;
Rutella, Sergio ;
Bonanno, Giuseppina ;
Contemi, Anna Maria ;
de Ritis, Daniela G. ;
Giannico, Maria Benedetta ;
Rebuzzi, Antonio G. ;
Leone, Giuseppe ;
Crea, Filippo .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2006, 111 (02) :202-208
[8]   Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction [J].
Massa, M ;
Rosti, V ;
Ferrario, M ;
Campanelli, R ;
Ramajoli, I ;
Rosso, R ;
De Ferrari, GM ;
Ferlini, M ;
Goffredo, L ;
Bertoletti, A ;
Klersy, C ;
Pecci, A ;
Moratti, R ;
Tavazzi, L .
BLOOD, 2005, 105 (01) :199-206
[9]   The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow [J].
Peled, A ;
Grabovsky, V ;
Habler, L ;
Sandbank, J ;
Arenzana-Seisdedos, F ;
Petit, I ;
Ben-Hur, H ;
Lapidot, T ;
Alon, R .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (09) :1199-1211
[10]   Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells [J].
Stellos, Konstantinos ;
Langer, Harald ;
Daub, Karin ;
Schoenberger, Tanja ;
Gauss, Alexandra ;
Geisler, Tobias ;
Bigalke, Boris ;
Mueller, Iris ;
Schumm, Michael ;
Schaefer, Iris ;
Seizer, Peter ;
Kraemer, Bjoern F. ;
Siegel-Axel, Dorothea ;
May, Andreas E. ;
Lindemann, Stephan ;
Gawaz, Meinrad .
CIRCULATION, 2008, 117 (02) :206-215
12