Vaccine-preventable anal infections by human papillomavirus among HIV-infected men who have sex with men

被引：4

作者：

Giuliani, Massimo ^{[1
]}

Latini, Alessandra ^{[1
]}

Colafigli, Manuela ^{[1
]}

Benevolo, Maria ^{[2
]}

Rollo, Francesca ^{[2
]}

Zaccarelli, Mauro ^{[3
]}

Giuliani, Eugenia ^{[4
]}

Moretto, Domenico ^{[5
]}

Giglio, Amalia ^{[5
]}

Rezza, Giovanni ^{[6
]}

Cristaudo, Antonio ^{[1
]}

Dona, Maria G. ^{[1
]}

机构：

[1] San Gallicano Dermatol Inst IRCCS, Clin & Expt Dermatol Dept, HIV STI Unit, Via Elio Chianesi 53, I-00144 Rome, Italy

[2] Regina Elena Natl Canc Inst IRCCS, Pathol Dept, Via Elio Chianesi 53, I-00144 Rome, Italy

[3] Ist Nazl Malattie Infett INMI Lazzaro Spallanzani, Clin & Res Dept, Via Portuense 292, I-00149 Rome, Italy

[4] Sapienza Univ, Dept Mol Med, Viale Regina Elena 291-293, I-00161 Rome, Italy

[5] San Gallicano Dermatol Inst IRCCS, Microbiol & Clin Pathol Dept, Via Elio Chianesi 53, I-00144 Rome, Italy

[6] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, Viale Regina Elena 299, I-00141 Rome, Italy

来源：

FUTURE MICROBIOLOGY | 2018年 / 13卷 / 13期

关键词：

anal; HIV; HPV; MSM; vaccine; HPV INFECTION; UNINFECTED MEN; POSITIVE MEN; RISK-FACTORS; PREVALENCE; CANCER; LESIONS; MSM; AGE; BURDEN;

D O I：

10.2217/fmb-2018-0149

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: HIV-infected men who have sex with men (MSM) show the highest prevalence of anal HPV infection. Anal prevalence of the HPVs targeted by the quadrivalent HPV vaccine (4vHPV) and nonavalent HPV vaccine (9vHPV) was estimated in this population. Materials & methods: Anal specimens were collected from HIV-infected MSM attending a sexually transmitted infection/HIV center. Specimens were analyzed using the Linear Array HPV Genotyping Test. Results: A total of 49.5 and 71.2% of the 313 enrolled MSM harbored at least one of the 4vHPV and 9vHPV types, respectively. A significantly decreasing trend was observed for the prevalence of both 4vHPV (p = 0.04) and 9vHPV types (p < 0.001) across age classes. Conclusion: A substantial proportion of HIV-infected MSM do not harbor a current anal infection with vaccine-preventable HPVs. The potential benefit of the 4vHPV versus 9vHPV vaccination in these subjects, including older MSM, should be investigated.

引用

页码：1463 / 1472

页数：10

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