Granulocyte Transfusions: A Critical Reappraisal

被引：18

作者：

Valentini, Caterina Giovanna ^{[1
]}

Farina, Francesca ^{[2
]}

Pagano, Livio ^{[1
]}

Teofili, Luciana ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Ist Ematol, Largo Francesco Vito 1, I-00168 Rome, Italy

[2] IRCCS San Raffaele, UO Ematol & Trapianto Midollo, Milan, Italy

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2017年 / 23卷 / 12期

关键词：

Granulocytes; Infections; Individualized medicine; Personalized therapies; COLONY-STIMULATING FACTOR; LIFE-THREATENING INFECTIONS; BLOOD-CELL TRANSFUSIONS; NEUTROPENIC PATIENTS; PEDIATRIC-PATIENTS; MYELOID PROGENITORS; G-CSF; HEMATOLOGICAL MALIGNANCIES; FUNGAL-INFECTIONS; PERIPHERAL-BLOOD;

D O I：

10.1016/j.bbmt.2017.07.029

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Granulocyte transfusions (GTs) are seldom used as a life-saving therapy for neutropenic patients with severe infections. Despite compelling evidence of GT efficacy in retrospective and prospective case series, no study has been successful in demonstrating a definite advantage for recipients in controlled clinical trials. This review critically revises some aspects emerging from past experience that might have weakened the evidence of GT benefits. Some specific issues relevant to the efficacy of this therapeutic approach, such as primary infection, delivered doses and schedules, and immunologic effects of GTs, are discussed. Importantly, the awareness of biologic effects accompanying the transfusion of neutrophils might support their use at standardized doses and may definitely convey significant advantages to the recipient patients. (C) 2017 American Society for Blood and Marrow Transplantation.

引用

页码：2034 / 2041

页数：8

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