Hyperosmolarity: Intracellular effects and implication in dry eye disease

被引：8
作者：
Warcoin, E. [1 ,2 ]
Clouzeau, C. [1 ]
Brignole-Baudouin, F. [1 ,3 ]
Baudouin, C. [1 ,4 ,5 ]
机构：
[1] Univ Paris 06, INSERM, CNRS, Inst Vis,Sorbonne Univ, 17,Rue Moreau, F-75012 Paris, France
[2] CHNO Quinze Vingts, Serv Pharm, F-75012 Paris, France
[3] Univ Paris 05, Fac Pharm Paris, Sorbonne Paris Cite, F-75006 Paris, France
[4] CHNO Quinze Vingts, Serv 3, F-75012 Paris, France
[5] Univ Versailles St Quentin En Yvelines, DHU Sight Restore, Hop Ambroise Pare, AP HP, F-78000 Versailles, France
来源：
JOURNAL FRANCAIS D OPHTALMOLOGIE | 2016年 / 39卷 / 07期
关键词：
Hyperc smolarity; Dry eye disease; NFAT5; Ocular surface; Inflammation; CORNEAL EPITHELIAL-CELLS; ACTIVATED PROTEIN-KINASE; TRANSCRIPTION FACTOR TONEBP/OREBP; INFLAMMATORY CYTOKINE RELEASE; CHRONIC HYPERTONIC STRESS; ENHANCER-BINDING PROTEIN; DAMAGE-INDUCIBLE KINASE; NACL-INDUCED ACTIVATION; COLLECTING DUCT CELLS; MURINE KIDNEY-CELLS;
D O I：
10.1016/j.jfo.2016.07.006
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Dry eye disease is a multifactorial disease affecting the lacrimal functional unit and which has a significant impact on the quality of life of patients. This pathology works as a vicious circle at the ocular surface in which hyperosmolarity of the tear film plays a key role. This review intends to describe the different reported intracellular effects induced by hyperosmolarity in cells: alteration of cytoskeleton, cell cycle slowdown, adaptation mechanisms triggered as restoration of cell volume and accumulation of compatible osmolytes, the crucial role of the osmoprotectant factor Nuclear Factor of the Activated T cells-5 (NFAT5), apoptosis, as well as oxidative stress and inflammatory responses caused by this particular condition. Reported effects of hyperosmolarity in the experimental studies specific of dry eye disease concerning ocular surface cells will be described in parallel. Indeed, these data allow to understand a part of the pathophysiology of the disease, and specially the links between tear hyperosmolarity and inflammation of the ocular surface, the second key of the pathology phenomenon. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：641 / 651
页数：11
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