Increased expression of PD1 and CD39 on CD3+CD4+ skin T cells in the elderly

被引：12

作者：

Zuelgaray, Elina ^{[1
,2
]}

Boccara, David ^{[2
,3
,4
]}

So, Sophie Ly Ka ^{[2
]}

Boismal, Francoise ^{[2
]}

Mimoun, Maurice ^{[2
,3
,4
]}

Bagot, Martine ^{[1
,2
,3
]}

Bensussan, Armand ^{[2
,3
]}

Bouaziz, Jean-David ^{[1
,2
,3
]}

Michel, Laurence ^{[2
,3
]}

机构：

[1] St Louis Hosp, Dermatol Dept, Paris, France

[2] St Louis Hosp, INSERM UMRS 976, Paris, France

[3] Paris Diderot Univ, Paris VII, Paris, France

[4] St Louis Hosp, Plast & Reconstruct Surg Dept, Paris, France

来源：

EXPERIMENTAL DERMATOLOGY | 2019年 / 28卷 / 01期

关键词：

ageing; ecto-nucleotidase CD39; PD1 inhibitory marker; skin innate lymphoid cells; skin T cells; INNATE LYMPHOID-CELLS; IMMUNOSENESCENCE;

D O I：

10.1111/exd.13842

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Normal ageing is associated with an impaired systemic immune response contributing to an increased susceptibility to infectious diseases. The aim of this study was to compare the lymphocyte phenotype in human skin from old and young healthy subjects. Skin samples from donors were used for explant cultures before flow cytometric analysis. Our results depicted a higher proportion of CD4(+) and a lower proportion of CD8(+) among CD3(+) T cells, a decreased proportion of CD45RA(+) naive T cells (3.5 +/- 1.9% vs 22.9 +/- 11.1%, P <= 0.007) and an upregulation of the expression of CD39 and PD1 on CD3(+)CD4(+) T cells (25.1 +/- 8.5% vs 12.5 +/- 8.5%, P <= 0.003, 68.8 +/- 11.6% vs 50.0 +/- 11.3%, P <= 0.01, respectively) in the skin of old subjects. These findings could explain a reduced generation of long-lived memory T cells and an impaired antitumoral response in the skin of the elderly.

引用

页码：80 / 82

页数：3

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