Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis

被引：16

作者：

Qu, H. C. ^{[1
]}

Zhang, W. ^{[2
]}

Liu, Y. L. ^{[1
]}

Wang, P. ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 4, Dept Urol Surg, Shenyang, Liaoning, Peoples R China

[2] China Med Univ, Dent Affiliated Hosp, Dept Orthodont, Shenyang, Liaoning, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 01期

关键词：

beta 3-adrenoceptor genes; Genetic polymorphism; Meta-analysis; Overactive bladder risk; SP1-BINDING SITE POLYMORPHISM; URINARY-BLADDER; BETA(3)-ADRENOCEPTOR; DETRUSOR; HETEROGENEITY; PHARMACOLOGY; SUBTYPES;

D O I：

10.4238/2015.March.30.7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic variations in the human beta 3-adrenoceptor (beta 3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the beta 3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we conducted a meta-analysis to explore the association between the Trp64Arg polymorphism and OAB risk. We examined 2 case-control studies, including a total of 149 OAB cases and 270 healthy controls. The meta-analysis results showed that the Arg allele of the beta 3-AR gene is positively associated with OAB susceptibility, while Arg allele carriers (Trp64Arg + Arg64Arg) showed positive associations with OAB. These results also demonstrated that the Trp64Arg polymorphism in the beta 3-AR gene is involved in the pathogenesis of OAB.

引用

页码：2495 / 2501

页数：7

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