Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men

被引：33

作者：

Mujica, AO

Brauksiepe, B

Saaler-Reinhardt, S

Reuss, S

Schmidt, ER

机构：

[1] Univ Mainz, Inst Mol Genet, D-55099 Mainz, Germany

[2] Univ Mainz, Inst Genet, D-6500 Mainz, Germany

[3] Univ Mainz, Dept Anat & Cell Biol, D-6500 Mainz, Germany

来源：

FEBS JOURNAL | 2005年 / 272卷 / 19期

关键词：

serine/threonine kinase; spermatogenesis; STK33; antibody; expression;

D O I：

10.1111/j.1742-4658.2005.04900.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serine/threonine kinase 33 (STK33/Stk33) is a recently discovered gene whose inferred amino acid sequence translation displays characters typical for a calcium/calmodulin dependent kinase (CAMK). In this study we analysed the STK33/Stk33 RNA and protein distribution and the localization of the protein. The STK33/Stk33 expression pattern resembles those of some related members of the CAMK group. STK33/Stk33 displays a nonubiquitous and, in most tissues, low level of expression. It is highly expressed in testis, particularly in cells from the spermatogenic epithelia. Moreover, significant expression is detected in lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. A possible role of STK33/Stk33 in spermatogenesis and organ ontogenesis is discussed.

引用

页码：4884 / 4898

页数：15

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