Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

被引：337
作者：
Podar, K
Tai, YT
Davies, FE
Lentzsch, S
Sattler, M
Hideshima, T
Lin, BK
Gupta, D
Shima, Y
Chauhan, D
Mitsiades, C
Raje, N
Richardson, P
Anderson, KC
机构：
[1] Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
来源：
BLOOD | 2001年 / 98卷 / 02期
关键词：
D O I：
10.1182/blood.V98.2.428
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon NIM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM. (C) 2001 by The American Society of Hematology.
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收藏
页码：428 / 435
页数：8
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