Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy

被引：446

作者：

Chun, Tae-Wook ^{[1
]}

Nickle, David C. ^{[6
]}

Justement, Jesse S. ^{[1
]}

Meyers, Jennifer H. ^{[1
]}

Roby, Gregg ^{[1
]}

Hallahan, Claire W. ^{[2
]}

Kottilil, Shyam ^{[1
]}

Moir, Susan ^{[1
]}

Mican, Joann M. ^{[4
]}

Mullins, James I. ^{[6
]}

Ward, Douglas J. ^{[7
]}

Kovacs, Joseph A. ^{[5
]}

Mannon, Peter J. ^{[3
]}

Fauci, Anthony S. ^{[1
]}

机构：

[1] NIAID, Immunoregulat Lab, Bethesda, MD 20892 USA

[2] NIAID, Biol Resources Branch, Bethesda, MD 20892 USA

[3] NIAID, Host Def Lab, Bethesda, MD 20892 USA

[4] NIAID, Div Clin Res, Bethesda, MD 20892 USA

[5] NIH, Ctr Clin, Dept Crit Care Med, Bethesda, MD 20892 USA

[6] Univ Washington, Dept Microbiol, Washington, DC USA

[7] Dupont Circle Physcians Grp, Washington, DC USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 05期

关键词：

D O I：

10.1086/527324

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV) persists in peripheral blood mononuclear cells despite sustained, undetectable plasma viremia resulting from long-term antiretroviral therapy. However, the source of persistent HIV in such infected individuals remains unclear. Given recent data suggesting high levels of viral replication and profound depletion of CD4(+) T cells in gut-associated lymphoid tissue (GALT) of animals infected with simian immunodeficiency virus and HIV-infected humans, we sought to determine the level of CD4(+) T cell depletion as well as the degree and extent of HIV persistence in the GALT of infected individuals who had been receiving effective antiviral therapy for prolonged periods of time. We demonstrate incomplete recoveries of CD4(+) T cells in the GALT of aviremic, HIV-infected individuals who had received up to 9.9 years of effective antiretroviral therapy. In addition, we demonstrate higher frequencies of HIV infection in GALT, compared with PBMCs, in these aviremic individuals and provide evidence for cross-infection between these 2 cellular compartments. Together, these data provide a possible mechanism for the maintenance of viral reservoirs revolving around the GALT of HIV-infected individuals despite long-term viral suppression and suggest that the GALT may play a major role in the persistence of HIV in such individuals.

引用

页码：714 / 720

页数：7

共 29 条

[1] CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract [J].