Usefulness of therapeutic drug monitoring in estimating the duration of dalbavancin optimal target attainment in staphylococcal osteoarticular infections: a proof-of-concept

被引:29
|
作者
Cojutti, Pier Giorgio [1 ]
Rinaldi, Matteo [2 ,3 ]
Gatti, Milo [1 ,2 ]
Tedeschi, Sara [2 ,3 ]
Viale, Pierluigi [2 ,3 ]
Pea, Federico [1 ,2 ]
机构
[1] IRCCS Azienda Osped Univ Bologna, SSD Clin Pharmacol, Bologna, Italy
[2] Univ Bologna, Dept Med & Surg Sci, Alma Mater Studiorum, Bologna, Italy
[3] IRCCS Azienda Osped Univ Bologna, Infect Dis Unit, Bologna, Italy
关键词
Therapeutic drug monitoring; TDM; Dalbavancin; Osteoarticular infection; Staphylococci; Duration of treatment; AUREUS; BONE;
D O I
10.1016/j.ijantimicag.2021.106445
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Dalbavancin is increasingly used for the treatment of staphylococcal osteoarticular infections (OIs). Some population pharmacokinetic studies suggest that a regimen of two 1500 mg doses 1 week apart could ensure effective treatment for several weeks. Here we aim to provide clinicians with a proof-of-concept of the potential role that therapeutic drug monitoring may have in giving real-time feedback of the estimated duration of optimal treatment of staphylococcal OIs with dalbavancin in each single patient. (c) 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
引用
收藏
页数:3
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