Association of the serotonin transporter promoter polymorphism with suicidal behavior

被引：27

作者：

Campi-Azevedo, AC

Boson, W

De Marco, L

Romano-Silva, MA

Correa, H

机构：

[1] Univ Fed Minas Gerais, ICB, Dept Morfol, BR-31228090 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, ICB, Lab Farmacogenet, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, ICB, Dept Farmacol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Grp Pesquisa Neuropsiquiatria Clin & Mol, Belo Horizonte, MG, Brazil

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 11期

关键词：

D O I：

10.1038/sj.mp.4001381

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The authors investigated a polymorphism of the regulatory region of the serotonin transporter gene in a well-characterized sample of in-patients and healthy controls. They found that carriers of a particular allele not only made more suicide attempts over time, but also displayed an enhancement of some aspects of the suicidal gesture-like violence, lethality and intent. These observations are remarkable because they are independent of the clinical diagnosis and, also, the demographic and sociocultural parameters investigated.

引用

页码：899 / 900

页数：3

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