Residual Dipolar Couplings for the Configurational and Conformational Analysis of Organic Molecules

被引：135
作者：
Kummerloewe, G. [1 ]
Luy, B. [1 ]
机构：
[1] Tech Univ Munich, Dept Chem, LS OC II, Lichtenbergstr 4, D-85747 Garching, Germany
来源：
ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 68 | 2009年 / 68卷
关键词：
NMR spectroscopy; RDCs; residual dipolar couplings; alignment media; structure; chirality; configuration; conformation; LIQUID-CRYSTALLINE MEDIUM; HIGH-RESOLUTION NMR; HOMONUCLEAR HARTMANN-HAHN; CHIRAL ORIENTED SOLVENTS; BROAD-BAND EXCITATION; BENZYL-L-GLUTAMATE; SELECTIVE REFOCUSING EXPERIMENTS; COHERENCE-TRANSFER-FUNCTIONS; PROTEIN-LIGAND COMPLEXES; ABUNDANCE DEUTERIUM NMR;
D O I：
10.1016/S0066-4103(09)06804-5
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Residual dipolar couplings (RDCs) have already revolutionized biomolecular NMR spectroscopy and are about to do the same in small molecule applications: impressive examples for conformational refinement of small sugars and peptides, the distinction of enantiomers and the determination of relative and absolute configuration have been published in recent years. After a short introduction into the basic theory, this article will give a review of existing alignment media, methods for scaling the alignment, pulse sequences for measuring RDCS and recent applications.
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页码：193 / +
页数：9
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