Combining Radiation- with Immunotherapy in Prostate Cancer: Influence of Radiation on T Cells

被引：3

作者：

Lindner, Diana ^{[1
,2
]}

Arndt, Claudia ^{[1
]}

Loureiro, Liliana Rodrigues ^{[1
]}

Feldmann, Anja ^{[1
]}

Kegler, Alexandra ^{[1
]}

Koristka, Stefanie ^{[1
]}

Berndt, Nicole ^{[1
]}

Mitwasi, Nicola ^{[1
]}

Bergmann, Ralf ^{[1
,3
]}

Frenz, Marcus ^{[4
]}

Bachmann, Michael P. ^{[1
,5
,6
,7
]}

机构：

[1] Helmholtz Zentrum Dresden Rossendorf, Inst Radiopharmaceut Canc Res, D-01328 Dresden, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Univ Canc Ctr UCC, Tumor Immunol, D-01307 Dresden, Germany

[3] Semmelweis Univ, Inst Biophys & Radiat Biol, H-1094 Budapest, Hungary

[4] Provadis Sch Int Management & Technol AG, Fac Informat & Wirtschaftsinformat, D-65926 Frankfurt, Germany

[5] Natl Ctr Tumor Dis NCT, Partner Site Dresden, D-01307 Dresden, Germany

[6] German Canc Consortium DKTK, Partner Site Dresden, D-69120 Heidelberg, Germany

[7] German Canc Res Ctr, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 14期

关键词：

prostate stem cell antigen; prostate cancer; radiation; immunotherapy; bispecific T cell engager; EFFECTOR-CELLS; ANTIBODY; ANTIGEN; THERAPY; LYMPHOCYTES; CD4(+); CD8(+); TUMORS;

D O I：

10.3390/ijms23147922

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radiation of tumor cells can lead to the selection and outgrowth of tumor escape variants. As radioresistant tumor cells are still sensitive to retargeting of T cells, it appears promising to combine radio- with immunotherapy keeping in mind that the radiation of tumors favors the local conditions for immunotherapy. However, radiation of solid tumors will not only hit the tumor cells but also the infiltrated immune cells. Therefore, we wanted to learn how radiation influences the functionality of T cells with respect to retargeting to tumor cells via a conventional bispecific T cell engager (BiTE) and our previously described modular BiTE format UNImAb. T cells were irradiated between 2 and 50 Gy. Low dose radiation of T cells up to about 20 Gy caused an increased release of the cytokines IL-2, TNF and interferon-gamma and an improved capability to kill target cells. Although radiation with 50 Gy strongly reduced the function of the T cells, it did not completely abrogate the functionality of the T cells.

引用

页数：16

共 55 条

[1] Building on Synthetic Immunology and T Cell Engineering: A Brief Journey Through the History of Chimeric Antigen Receptors [J].

Abken, Hinrich .

HUMAN GENE THERAPY, 2021, 32 (19-20) :1011-1028

[2]

Albert Susann, 2018, Oncotarget, V9, P25597, DOI 10.18632/oncotarget.25390

[3] Adaptor CAR Platforms-Next Generation of T Cell-Based Cancer Immunotherapy [J].

Arndt, Claudia ;

Fasslrinner, Frederick ;

Loureiro, Liliana R. ;

Koristka, Stefanie ;

Feldmann, Anja ;

Bachmann, Michael .

CANCERS, 2020, 12 (05)

[4] UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells [J].

Arndt, Claudia ;

Loureiro, Liliana R. ;

Feldmann, Anja ;

Jureczek, Justyna ;

Bergmann, Ralf ;

Mathe, Domokos ;

Hegedues, Nikolett ;

Berndt, Nicole ;

Koristka, Stefanie ;

Mitwasi, Nicola ;

Fasslrinner, Frederick ;

Lamprecht, Chris ;

Kegler, Alexandra ;

Hoffmann, Anja ;

Bartsch, Tabea ;

Koeseer, Ayse Sedef ;

Egan, Gary ;

Schmitz, Marc ;

Horejsi, Vaclav ;

Krause, Mechthild ;

Dubrovska, Anna ;

Bachmann, Michael .

ONCOIMMUNOLOGY, 2020, 9 (01)

[5] A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR [J].

Arndt, Claudia ;

Feldmann, Anja ;

Koristka, Stefanie ;

Schaefer, Martin ;

Bergmann, Ralf ;

Mitwasi, Nicola ;

Berndt, Nicole ;

Bachmann, Dominik ;

Kegler, Alexandra ;

Schmitz, Marc ;

Puentes-Cala, Edinson ;

Andres Soto, Javier ;

Ehninger, Gerhard ;

Pietzsch, Jens ;

Liolios, Christos ;

Wunderlich, Gerd ;

Kotzerke, Joerg ;

Kopka, Klaus ;

Bachmann, Michael .

ONCOIMMUNOLOGY, 2019, 8 (11)

[6] Theranostic CAR T cell targeting: A brief review [J].

Arndt, Claudia ;

Bachmann, Michael ;

Bergmann, Ralf ;

Berndt, Nicole ;

Feldmann, Anja ;

Koristka, Stefanie .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019, 62 (08) :533-540

[7] Redirection of CD4+ and CD8+ T lymphocytes via a Novel Antibody-Based Modular Targeting System Triggers Efficient Killing of PSCA+ Prostate Tumor Cells [J].

Arndt, Claudia ;

Feldmann, Anja ;

Toepfer, Katrin ;

Koristka, Stefanie ;

Cartellieri, Marc ;

Temme, Achim ;

Ehninger, Armin ;

Ehninger, Gerhard ;

Bachmann, Michael .

PROSTATE, 2014, 74 (13) :1347-1358

[8] Simultaneous Targeting of Prostate Stem Cell Antigen and Prostate-Specific Membrane Antigen Improves the Killing of Prostate Cancer Cells Using a Novel Modular T Cell-Retargeting System [J].

Arndt, Claudia ;

Feldmann, Anja ;

Koristka, Stefanie ;

Cartellieri, Marc ;

Dimmel, Maria ;

Ehninger, Armin ;

Ehninger, Gerhard ;

Bachmann, Michael .

PROSTATE, 2014, 74 (13) :1335-1346

[9] The UniCAR system: A modular CAR T cell approach to improve the safety of CAR T cells [J].

Bachmann, Michael .

IMMUNOLOGY LETTERS, 2019, 211 :13-22

[10] Radiation oncology in the era of precision medicine [J].

Baumann, Michael ;

Krause, Mechthild ;

Overgaard, Jens ;

Debus, Juergen ;

Bentzen, Soren M. ;

Daartz, Juliane ;

Richter, Christian ;

Zips, Daniel ;

Bortfeld, Thomas .

NATURE REVIEWS CANCER, 2016, 16 (04) :234-249

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