Xenimanadins A-D, a family of xenicane diterpenoids from the Indonesian soft coral Xenia sp.

被引：19

作者：

Fattorusso, Ernesto ^{[1
]}

Romano, Adriana ^{[1
]}

Taglialatela-Scafati, Orazio ^{[1
]}

Achmad, M. Janib ^{[2
]}

Bavestrello, Giorgio ^{[3
]}

Cerrano, Carlo ^{[4
]}

机构：

[1] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Manado 95115, Indonesia

[3] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy

[4] Univ Genoa, Dipartimento Studio Territorio & Sue Risorse, I-16132 Genoa, Italy

来源：

TETRAHEDRON | 2008年 / 64卷 / 14期

关键词：

Xenia soft corals; Indonesia; diterpenes; structure elucidation; NMR;

D O I：

10.1016/j.tet.2008.01.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four novel xenicane diterpenoids, xenimanadins A-D (1-4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3141 / 3146

页数：6

共 14 条

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