Xenimanadins A-D, a family of xenicane diterpenoids from the Indonesian soft coral Xenia sp.

被引：19

作者：

Fattorusso, Ernesto ^{[1
]}

Romano, Adriana ^{[1
]}

Taglialatela-Scafati, Orazio ^{[1
]}

Achmad, M. Janib ^{[2
]}

Bavestrello, Giorgio ^{[3
]}

Cerrano, Carlo ^{[4
]}

机构：

[1] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Manado 95115, Indonesia

[3] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy

[4] Univ Genoa, Dipartimento Studio Territorio & Sue Risorse, I-16132 Genoa, Italy

来源：

TETRAHEDRON | 2008年 / 64卷 / 14期

关键词：

Xenia soft corals; Indonesia; diterpenes; structure elucidation; NMR;

D O I：

10.1016/j.tet.2008.01.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four novel xenicane diterpenoids, xenimanadins A-D (1-4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3141 / 3146

页数：6

共 14 条

[1] Induction of apoptosis by diterpenes from the soft coral Xenia elongata [J].

Andrianasolo, Eric H. ;

Haramaty, Liti ;

Degenhardt, Kurt ;

Mathew, Robin ;

White, Eileen ;

Lutz, Richard ;

Falkowski, Paul .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (10) :1551-1557

[2] New xenia diterpenoids from the Indonesian soft coral Xenia sp. [J].

Anta, C ;

González, N ;

Santafé, G ;

Rodríguez, J ;

Jiménez, C .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (05) :766-768

[3] Novaxenicins A-D and xeniolides I-K, seven new diterpenes from the soft coral Xenia novaebrittanniae [J].

Bishara, Ashgan ;

Rudi, Amira ;

Goldberg, Israel ;

Benayahu, Yehuda ;

Kashman, Yoel .

TETRAHEDRON, 2006, 62 (51) :12092-12097

[4] Marine natural products [J].

Blunt, John W. ;

Copp, Brent R. ;

Hu, Wan-Ping ;

Munro, Murray H. G. ;

Northcote, Peter T. ;

Prinsep, Michele R. .

NATURAL PRODUCT REPORTS, 2007, 24 (01) :31-86

[5] Xenicane-type diterpenes with cytotoxicity from Xenia florida [J].

Cheng, YB ;

Jang, JY ;

Khalil, AT ;

Kuo, YH ;

Shen, YC .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (04) :675-678

[6] New cytotoxic xenia diterpenoids from the formosan soft coral Xenia umbellata [J].

Duh, CY ;

El-Gamal, AAH ;

Chiang, CY ;

Chu, CJ ;

Wang, SK ;

Dai, CF .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (12) :1882-1885

[7]

EIGAMAL AAH, 2005, ORG LETT, V7, P2023

[8] Xenia diterpenoids from the formosan soft coral Xenia blumi [J].

El-Gamal, AAH ;

Chiang, CY ;

Huang, SH ;

Wang, SK ;

Duh, CY .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (09) :1336-1340

[9] NEW XENIA DITERPENOIDS FROM A SOFT CORAL XENIA SPECIES [J].

IWAGAWA, T ;

AMANO, Y ;

HASE, T ;

SHIRO, M .

TETRAHEDRON, 1995, 51 (41) :11111-11118

[10] New xenia diterpenoids from a Xenia species of a soft coral [J].

Iwagawa, T ;

Masuda, T ;

Okamura, H ;

Nakatani, M .

TETRAHEDRON, 1996, 52 (41) :13121-13128

← 1 2 →