A concise access to 2-allenylindole derivatives based on the palladium catalyzed cross-coupling reaction of indolylborates

被引:29
作者
Ishikura, M [1 ]
Matsuzaki, Y [1 ]
Agata, I [1 ]
Katagiri, N [1 ]
机构
[1] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan
关键词
indolylborate; allenylindole; cross-coupling reaction; prop-2-ynylindole;
D O I
10.1016/S0040-4020(98)00861-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The palladium catalyzed cross-coupling reaction of trialky](indol-2-yl)borates with prop-2-ynyl carbonates was developed for the preparation of 2-allenylindole derivatives. When the reaction of indolyl-borates with tert-prop-2-ynyl carbonates was carried out. 2-allenylindoles were obtained solely. Otherwise, indolylborates reacted with sec-prop-2-ynyl carbonates, giving rise to 2-allenylindoles and/or 3-(prop-2-ynyl)indoles depending on the catalyst used. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:13929 / 13942
页数:14
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