Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases

被引：75

作者：

Ye, Cheng ^{[1
]}

Yano, Hiroshi ^{[1
,2
]}

Workman, Creg J. ^{[1
]}

Vignali, Dario A. A. ^{[1
,3
,4
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA

[2] Weill Cornell Med, Jill Roberts Inst Res Inflammatory Bowel Dis, New York, NY USA

[3] UPMC Hillman Canc Ctr, Tumor Microenvironm Ctr, Pittsburgh, PA USA

[4] UPMC Hillman Canc Ctr, Canc Immunol & Immunotherapy Program, Pittsburgh, PA USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2021年 / 41卷 / 11期

基金：

美国国家卫生研究院;

关键词：

IL-35; cancer; autoimmune diseases; infection; REGULATORY T-CELLS; INDUCED GENE 3; B-CELLS; DENDRITIC CELLS; SIGNAL TRANSDUCER; INDUCED ARTHRITIS; INTERFERON-GAMMA; PERIPHERAL-BLOOD; SERUM-LEVELS; IL-35;

D O I：

10.1089/jir.2021.0147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The balance between inflammatory and anti-inflammatory immune responses is maintained through immunoregulatory cell populations and immunosuppressive cytokines. Interleukin-35 (IL-35), an inhibitory cytokine that belongs to the IL-12 family, is capable of potently suppressing T cell proliferation and inducing IL-35-producing induced regulatory T cells (iTr35) to limit inflammatory responses. Over the past decade, a growing number of studies have indicated that IL-35 plays an important role in controlling immune-related disorders, including autoimmune diseases, infectious diseases, and cancer. In this review, we summarize the current knowledge about the biology of IL-35 and its contribution in different diseases, and we discuss the potential of and barriers to harnessing IL-35 as a clinical biomarker or immunotherapy.

引用

页码：391 / 406

页数：16

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