Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications

被引：78

作者：

Jung, Ho Sang ^{[1
]}

Lee, Taekyung ^{[2
]}

Kwon, Il Keun ^{[4
,5
]}

Kim, Hyoung Seop ^{[1
]}

Hahn, Sei Kwang ^{[1
]}

Lee, Chong Soo ^{[1
,3
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Mat Sci & Engn, Pohang 790784, Kyungbuk, South Korea

[2] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[3] Pohang Univ Sci & Technol POSTECH, GIFT, Pohang 790784, Kyungbuk, South Korea

[4] Kyung Hee Univ, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea

[5] Kyung Hee Univ, Inst Oral Biol, Sch Dent, Seoul 130701, South Korea

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

graphene; titanium alloy; pi-pi stacking; dental implant; osseointegration; SEVERE PLASTIC-DEFORMATION; BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; TITANIUM-ALLOYS; GRAIN-STRUCTURE; CARBON STEEL; DIFFERENTIATION; TI-13NB-13ZR; STRENGTH; BEHAVIOR;

D O I：

10.1021/acsami.5b03431

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Titanitim (Ti) and its alloys with a high mechanical strength and a small diameter an be effectively exploited for minimally invasive dental implantation. Here, we report a. multipass: caliber-rolled Ti alloy of Til3Nh13Zr (MPCR-TNZ) with a high mechanical strength and strong fatigue characteristies. For further dental applications, MPCR-TNZ was surface-modified With reduced,graphene, oxide (RGO) and loaded with osteogenic dexamethasone (Dex) via pi-pi stacking on the graphitic domain of RGO, The Dex-loaded RGO-MPCR-TNZ (Dex/RGO-MFCR-TN) resulted in significantly enhanced gi-owth and differentiation of MC3T3-E1 cells into osteoblasts, which was confirthed by Alizarin red staining, alkaline phosphatase activity test, immunocytochemistry, and real-time PCR. Moreover, we could confirm the feasibility of Dex/RGO-MPCR-TNZ from the implantation test of a prototype of a dental implant to an artificial bone block for clinical dental applications.

引用

页码：9598 / 9607

页数：10

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