The biology of immunoglobulin free light chains and kidney injury

被引：83
作者：
Basnayake, Kolitha [1 ,2 ]
Stringer, Stephanie J. [1 ,2 ]
Hutchison, Colin A. [1 ,2 ]
Cockwell, Paul [1 ,2 ]
机构：
[1] Univ Hosp Birmingham, Renal Inst Birmingham, Birmingham B15 2TH, W Midlands, England
[2] Univ Birmingham, Sch Immun & Infect, Birmingham, W Midlands, England
来源：
KIDNEY INTERNATIONAL | 2011年 / 79卷 / 12期
关键词：
cell signaling; chronic kidney disease; cytokines; fibrosis; myeloma; TAMM-HORSFALL PROTEIN; BENCE-JONES PROTEINS; STEM-CELL TRANSPLANTATION; MOLECULAR-WEIGHT PROTEINS; AMYLOID P-COMPONENT; GLOMERULAR EXTRACELLULAR-MATRIX; PRIMARY SYSTEMIC AMYLOIDOSIS; TUBULAR EPITHELIAL-CELLS; ACUTE-RENAL-FAILURE; FACTOR-KAPPA-B;
D O I：
10.1038/ki.2011.94
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury. Kidney International (2011) 79, 1289-1301; doi:10.1038/ki.2011.94; published online 13 April 2011
引用
收藏
页码：1289 / 1301
页数：13
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