Black soybean-derived peptides exerted protective effect against alcohol-induced liver injury in mice

被引：31

作者：

Ren, Jian ^{[1
]}

Li, Sijin ^{[1
]}

Song, Chunli ^{[1
]}

Sun, Xiaohong ^{[1
]}

Liu, Xiaolan ^{[1
]}

机构：

[1] Qiqihar Univ, Heilongjiang Prov Key Univ Lab Proc Agr Prod, Coll Food & Bioengn, Qiqihar 161006, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 87卷

关键词：

Alcalase; Bioactive peptides; Alcoholic liver injury; Antioxidant; Anti-inflammation; Amino acid composition; OXIDATIVE STRESS; CORN PEPTIDE; IN-VITRO; ANTIOXIDANT; METABOLISM; DISEASE; PATHOGENESIS; INGESTION; MEAL; ACID;

D O I：

10.1016/j.jff.2021.104828

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Alcoholic liver disease is one of the most prevalent chronic diseases that causes high morbidity and mortality worldwide. This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice. BSPs were rich in oligopeptides (80%, w/w, <1,996 Da) and Lys. The median and high doses of BSPs (400-800 mg/kg.Mw) decreased the levels of AST, ALT in serum. Only high dose of BSPs decreased the triglyceride content to normal level (P > 0.05). All treatments significantly (P < 0.01) reduced the creatinine level compared to the model group. The histopathological examination further confirmed the protective effect of BSPs. This protective effect is possibly attributed to the antioxidant and anti-inflammatory activities of BSPs due to the increased levels of GSH, SOD and CAT and decreased contents of MDA, IL-6 and IL-1 beta compared to those of model group.

引用

页数：7

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